摘要
Problem: Major depressive disorder (MDD) is the leading cause of disability worldwide, but approximately one-third of patients do not respond to current treatment options. Many prior studies suggest that gut microbiota have a strong influence on the brain, thus manipulation of gut microbiota could be a viable treatment option for patients with MDD. Probiotics can offer positive benefits to the gut, and a healthy gut can lead to positive benefits for the brain. Purpose: To identify the effects of probiotics as adjunctive treatment to pharmacotherapy in patients with MDD. Research Question: Does the use of probiotics as adjunctive treatment to pharmacotherapy improve symptoms in patients diagnosed with MDD? Methods: A prospective double-blind randomized controlled trial using a paired t-test to analyze improvements in the symptoms of MDD outlined by the DSM-5 (ie, depressed mood or loss of interest or pleasure) based on the results of three self-reported questionnaires. Outcomes: The results will demonstrate if the use of probiotics as adjunctive treatment to pharmacotherapy will provide significantly improved symptoms of MDD compared to the control group. Benefit: To promote further exploration of the bidirectional relationship between the gut and the brain to identify additional and adjunctive treatment options for major depressive disorder.
摘要译文
问题：主要抑郁症（MDD）是全球残疾的主要原因，但大约三分之一的患者不响应当前的治疗方案。许多先前的研究表明，肠道微生物会对大脑产生强烈影响，因此肠道微生物瘤的操纵可以是MDD患者的可行治疗选择。益生菌可以为肠道提供积极的益处，健康的肠道会导致大脑的积极效益。目的：鉴定益生菌对MDD患者药物治疗的辅助治疗。研究问题：使用益生菌作为药物疗法的辅助治疗是否改善患者诊断MDD的症状？方法：采用配对T检验的预期双盲随机对照试验，以分析DSM-5（即，感兴趣的情绪或悲伤或乐趣丧失的MDD症状的改善，基于三自行的结果报告的问卷。结果：结果将展示使用益生菌作为药物治疗的辅助治疗将提供与对照组相比的MDD的显着改善。益处：促进肠道与大脑之间双向关系的进一步探索，以确定主要抑郁症的其他和辅助治疗方案。
Ruggiero, Mia. Go with Your Gut: The Use of Probiotics as Adjunctive Treatment in Major Depressive Disorder[D]. US: Weill Medical College of Cornell University, 2021