期刊文献

The Effect of Estrogen on Fetal Survival in Progesterone-Treated Ovariectomized Rats 收藏

雌激素对孕激素治疗的去卵巢大鼠胎儿存活的影响
原文求助 发布源
作者
HIROMICHI TAMADA[1];SHIGETAKA ICHIKAWA[1]
作者单位
[1]Laboratory of Animal Reproduction, College of Agriculture, University of Osaka Prefecture
页码
163-167
DOI
10.1507/endocrj1954.27.163
来源信息
Endocrinologia Japonica ISSN：0013-7219, 1980年, 27卷, 2期, 163-167页
摘要
In pregnant rats ovariectomized on Day 14 of pregnancy (sperm present=Day1), the daily injection of 4mg progesterone maintained normal pregnancy up to Day 17, but injured fetuses bearing hematomata on their extremities appeared very frequently there after, in spite of successive injections of progesterone. The addition of 0.2μg estradiol-17β to the daily dose of progesterone for two suc-cessive days between Days 15 and 18 of pregnancy prevented the occurrence of fetal injuries. Estradiol-17β was found to be more effective in preventing fetal damage than estrone or estriol. The results suggest that while progesterone is essential for the maintenance of pregnancy, estrogen is also necessary at the time when the conceptus elongates and becomes cylindrical.
摘要译文
在孕期第14天去卵巢的怀孕大鼠（精子存在\x3d第1天）中，每天注射4mg黄体酮直至第17天保持正常妊娠，但在其后四周出现带有四肢血肿的受伤胎儿，尽管连续注射黄体酮。在妊娠第15天至第18天之间的两个连续日内向雌孕激素的每日剂量中加入0.2μg雌二醇-17β可防止胎儿受伤的发生。发现雌二醇-17β比雌酮或雌三醇更有效地预防胎儿损伤。结果表明，虽然孕酮对于维持妊娠至关重要，但当概念伸长并变成圆柱形时，雌激素也是必需的。
HIROMICHI TAMADA[1];SHIGETAKA ICHIKAWA[1]. The Effect of Estrogen on Fetal Survival in Progesterone-Treated Ovariectomized Rats[J]. Endocrinologia Japonica, 1980,27(2): 163-167