摘要
Pregnant rats ovariectomized on day 14 of pregnancy (Sperm present = day 1) were daily treated with 4 mg progesterone (P) plus androgens, and the effects of the androgens on fetal survival and intrauterine pressure were examined on day 20 of pregnancy. In the rats treated with P only, the percentage of live normal fetuses was only 40.4% of the total fetuses, 39.4% were injured fetuses having hematomata on their extremities, and 20.2% were absorbing. Intrauterine pressure was about three times higher than that in the sham-operated controls. Treatment with androgen as well significantly increased the percentage of live normal fetuses and decreased intrauterine pressure, as estrogen did. A significant negative correlation was observed between the percentage of live normal fetuses and intra-uterine pressure. Androstendiol (A-diol) was most effective and its daily dose of 2 pM maintained normal pregnancy. A-diol and dehydroepiandrosterone (DHA) were more effective than androstendione (A-dione) and testosterone (T), suggesting that the effect of the former two androgens is not by conversion to estrogen, but by their direct action on the uterine wall. 5α-dihydrotestosterone, a non-aromatizable androgen, also exhibited moderate estrogenic action.
摘要译文
每天用4 mg孕激素（P）加雄激素治疗怀孕第14天（精子=第1天）的孕妇卵巢切除术，并在妊娠第20天检查雄激素对胎儿存活和宫内压力的影响。在仅用P治疗的大鼠中，活的正常胎儿的百分比仅占胎儿总胎儿的40.4％，39.4％的受伤的胎儿在四肢肿瘤，有20.2％的人正在吸收。宫内压的压力是假手术对照中的压力的三倍。像雌激素一样，用雄激素的治疗也显着增加了生命正常胎儿的百分比和宫内压力的降低。观察到活的正常胎儿的百分比和北极水的压力之间观察到显着的负相关。雄激素（A-二醇）最有效，其每日剂量为2 pm，保持正常的妊娠。A-二醇和脱氢表雄酮（DHA）比雄激素（A-Dione）和睾丸激素（T）更有效，这表明前两个雄激素的作用不是通过转化为雌激素，而是通过其对子宫壁的直接作用。5α-二氢睾丸激素是一种不可芳香的雄激素，也表现出中度的雌激素作用。
Kazumi HOSODA [1];Hiromichi TAMADA [2];Shigetaka ICHIKAWA [3];. The Effect of Androgen on the Maintenance of Pregnancy in Progesterone-treated Ovariectomized Rats[J]. 日本内分泌学会雑誌, 1984,60(1): 63-69