摘要
Scabiosa artropurperea var.maritima is a plant widely distributed in the Mediterranean region and used as a traditional medicine. The present study evaluated the biochemical composition and the potential toxicity of aqueous extract of whole Scabiosa artropurperea var.maritima through acute toxicity oral administration in male mice. Phytochemical analysis of the Scabiosa artropurperea var.maritima revealed high levels of reductor sugars and significant flavonoid and total phenol content. The aqueous extract of Scabiosa artropurperea var.maritima was daily oral administered to mice at doses of 300 (group 1), 2000 (group 2) and 4000 (group 3) mg/kg body weight per day for 14 days. We observed no significant difference in the consumption of food, body weight and relative organ weights except for an increase in the seminal vesicles weight in group 3. Hematological parameters revealed the non-adverse effects of prolonged oral consumption of Scabiosa artropurperea var.maritima except for a slight increase but significant of percentage of hematocrit in group 1 and 3 and a decrease in percentage of granulocytes in group 2. The histopathologic examination did not show any differences in vital organs. We also observed non-adverse effects on the reproductive parameters including testosterone concentration, spermatozoa motility and morphologies. Based on our findings, the aqueous extract of Scabiosa artropurperea var.maritima could be considered safe for oral medication in animals.
摘要译文
scabiosa artropurperea var.maritima是一种广泛分布在地中海地区的植物，并用作传统药物。本研究评估了整个scabiosa artropurperea var.maritima的生化组成和潜在的毒性，这是通过雄性小鼠口服给药的。scabiosa artropurperea var.maritima的植物化学分析显示，还原糖和明显的类黄酮和总苯酚含量。scabiosa artropurperea var.maritima的水提取物每天以300剂量（第1组），2000年（第2组）和4000（第3组）（3组）Mg/kg体重每天14天给小鼠施用。我们观察到食物，体重和相对器官重量的消耗没有显着差异，除了第3组的精液囊泡重量增加，血液学参数显示出长时间口服scabiosa artropurperea var.maritima的不良影响。第1组和第3组血细胞比容的百分比略有增加，以及第2组粒细胞的百分比减少。组织病理学检查没有显示重要器官的任何差异。我们还观察到对生殖参数（包括睾丸激素浓度，精子运动性和形态）的非不利影响。根据我们的发现，scabiosa artropurperea var.maritima的水提取物可以被认为是动物口服药物的安全。
Joëlle Dupont [a]. Evaluation of acute toxicity of Scabiosa artropurperea var.maritima aqueous extracts in Swiss mice[J]. Toxicon, 2024,239: 107614