摘要
The community of microorganisms colonising the human gastrointestinal tract (GIT) is a requisite contributor in host pathophysiology and immune interaction. This symbiotic relationship is synchronised by a sophisticated cross-talk with the central nervous system via metabolic and neuroendocrine routes. The gut microbiota interacts with almost all human cells in the body, with significant effect on mental health and brain homeostasis. The complexity of gut microbiota and its interactions in manifesting physiological changes in the brain has been the subject to scrutiny. The synergistic communication, signaling between the human gut and the brain is termed the Microbiota–Gut–Brain Axis (MGBA). There is a consecutive reciprocity between the intestinal colonisers and the brain, by virtue of which is an eminent cross-sectional association with some neuropsychiatric disorders. Dysbiosis in the gut microbiome not only harms the GIT functioning, but also impairs the normal neuronal functioning, resulting in mental health disorders. Since the microbiota of the individuals differ from one another, further research on the molecular and the biochemical basis of the microbiota–gut–brain axis is of paramount importance. Probiotic-based therapeutics are advocated to improve mental health disorders through an intervention of the gut–brain axis, thus exposing a futuristic approach towards disease treatment. This chapter summarises the current understanding of the gut–brain axis and its association with mental health and overall mental well-being.
摘要译文
The community of microorganisms colonising the human gastrointestinal tract (GIT) is a requisite contributor in host pathophysiology and immune interaction. This symbiotic relationship is synchronised by a sophisticated cross-talk with the central nervous system via metabolic and neuroendocrine routes. The gut microbiota interacts with almost all human cells in the body, with significant effect on mental health and brain homeostasis. The complexity of gut microbiota and its interactions in manifesting physiological changes in the brain has been the subject to scrutiny. The synergistic communication, signaling between the human gut and the brain is termed the Microbiota–Gut–Brain Axis (MGBA). There is a consecutive reciprocity between the intestinal colonisers and the brain, by virtue of which is an eminent cross-sectional association with some neuropsychiatric disorders. Dysbiosis in the gut microbiome not only harms the GIT functioning, but also impairs the normal neuronal functioning, resulting in mental health disorders. Since the microbiota of the individuals differ from one another, further research on the molecular and the biochemical basis of the microbiota–gut–brain axis is of paramount importance. Probiotic-based therapeutics are advocated to improve mental health disorders through an intervention of the gut–brain axis, thus exposing a futuristic approach towards disease treatment. This chapter summarises the current understanding of the gut–brain axis and its association with mental health and overall mental well-being.
Sagnik Nag[1];Ankita Saini[2];Richismita Hazra,[3];Jutishna Bora[4];Sagnik Nag[1];Ankita Saini[2];Richismita Hazra,[3];Jutishna Bora[4];Nimmy Srivastava[5];Salam Ibrahim[6];Jayeeta Chattopadhyay[7];Mohamed Arbab[8]. Impact of Gut Microbiota on Mental Health in Humans. The Gut Microbiota in Health and Disease[M].US: Wiley, 2023: 153-167