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How Brain Infarction Links With the Microbiota–Gut–Brain Axis: Hints From Studies Focusing on the Risk Factors for Ischemic Stroke 收藏

How Brain Infarction Links With the Microbiota–Gut–Brain Axis: Hints From Studies Focusing on the Risk Factors for Ischemic Stroke
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关键词
Microbiota-gut-brain axis; ischemic stroke; Risk factors; Dysbiosis;
关键词译文
Microbiota-gut-brain axis; ischemic stroke; Risk factors; Dysbiosis;
发布日期
2022
DOI
10.3389/fnins.2022.877937
来源信息
Neuroscience ISSN：1662-453X, 2022年, 16卷
摘要
Ischemic stroke (IS) is among the top prevalent neurologic disorders globally today. Risk factors including hypertension, diabetes and aging etc. contribute to the development of IS, and patients with these risk factors face heavier therapeutic burden and worse prognosis. Microbiota-gut-brain axis describes the crosstalk between the gut flora, intestine and center nervous system, which conduct homeostatic effects through the bacterial metabolites, the regulation of immune activity, also the contact with enteritic nerve ends and vagus nerve. Nowadays, more studies have paid attention to the important roles that microbiota-gut-brain axis played in the risk factors of IS. In the current article, we will review the recent works focusing on the bi-directional impacts of gut dysbiosis and the pathogenic process of IS related risk factors, for the purpose to summarize some novel findings in this area, and try to understand how probiotics could limit the development of IS via different strategies.
摘要译文
Ischemic stroke (IS) is among the top prevalent neurologic disorders globally today. Risk factors including hypertension, diabetes and aging etc. contribute to the development of IS, and patients with these risk factors face heavier therapeutic burden and worse prognosis. Microbiota-gut-brain axis describes the crosstalk between the gut flora, intestine and center nervous system, which conduct homeostatic effects through the bacterial metabolites, the regulation of immune activity, also the contact with enteritic nerve ends and vagus nerve. Nowadays, more studies have paid attention to the important roles that microbiota-gut-brain axis played in the risk factors of IS. In the current article, we will review the recent works focusing on the bi-directional impacts of gut dysbiosis and the pathogenic process of IS related risk factors, for the purpose to summarize some novel findings in this area, and try to understand how probiotics could limit the development of IS via different strategies.
How Brain Infarction Links With the Microbiota–Gut–Brain Axis: Hints From Studies Focusing on the Risk Factors for Ischemic Stroke[J]. Neuroscience, 2022,16