摘要
One of the crucial elements in sustaining host health and disease is the gut microbiota. The gut microbiota is now recognized as one of the critical elements in controlling the interactions between the gut and the brain due to growing advancement of omics techniques. Age-related changes in the gut microbiome contribute to the ageing process of the brain and that further leads to different neurodegenerative diseases. The idea that the gut can affect central nervous system’s (CNS) function and vice versa is becoming more widely accepted, giving rise to the microbiota-gut-brain axis as a communication pathway. A healthy body depends on maintaining a balanced gut microbiota, but dysbiosis can lead to several chronic diseases. Identifying biomarkers for chronic conditions associated with ageing will be made easier by understanding the underlying mechanisms of gut microbiota alterations and dysbiosis. Dysbiosis gut microbiota is linked to increased intestinal permeability, worsened neuroinflammation, oxidative stress and reduced neurotransmitter production, all of which are known to be crucial to the occurrence and progression of Parkinson’s disease (PD). This has made the gut microbiota a promising diagnostic and therapeutic target for PD by inculcating treatments using prebiotics, probiotics and antibiotics.
摘要译文
One of the crucial elements in sustaining host health and disease is the gut microbiota. The gut microbiota is now recognized as one of the critical elements in controlling the interactions between the gut and the brain due to growing advancement of omics techniques. Age-related changes in the gut microbiome contribute to the ageing process of the brain and that further leads to different neurodegenerative diseases. The idea that the gut can affect central nervous system’s (CNS) function and vice versa is becoming more widely accepted, giving rise to the microbiota-gut-brain axis as a communication pathway. A healthy body depends on maintaining a balanced gut microbiota, but dysbiosis can lead to several chronic diseases. Identifying biomarkers for chronic conditions associated with ageing will be made easier by understanding the underlying mechanisms of gut microbiota alterations and dysbiosis. Dysbiosis gut microbiota is linked to increased intestinal permeability, worsened neuroinflammation, oxidative stress and reduced neurotransmitter production, all of which are known to be crucial to the occurrence and progression of Parkinson’s disease (PD). This has made the gut microbiota a promising diagnostic and therapeutic target for PD by inculcating treatments using prebiotics, probiotics and antibiotics.
M. Swathi, Avipsa Hazra, A. S. Dhanu & Kanthesh M. Basalingappa[1];Surajit Pathak [2];Antara Banerjee [3]. Exploring the Interplay Between Gut Microflora and Parkinson’s. Gut Microbiome and Brain Ageing Brain Aging[M].DE: Springer, 2024: 307-333