摘要
Celiac disease (CeD) is an immune-mediated enteropathy, and unique in that the specific trigger is known: gluten. The current mainstay of therapy is a gluten-free diet (GFD). As novel therapies are being developed, complementary strategies are also being studied, such as modulation of the gut microbiome. The gut microbiota is involved in the initiation and perpetuation of intestinal inflammation in several chronic diseases. Intestinal dysbiosis has been reported in CeD patients, untreated or treated with GFD, compared to healthy subjects. Several studies have identified differential bacterial populations associated with CeD patients and healthy subjects. However, it is still not clear if intestinal dysbiosis is the cause or effect of CeD. Probiotics have also been considered as a strategy to modulate the gut microbiome to an anti-inflammatory state. However, there is a paucity of data to support their use in treating CeD. Further studies are needed with therapeutic microbial formulations combined with human trials on the use of probiotics to treat CeD by restoring the gut microbiome to an anti-inflammatory state.
摘要译文
乳糜泻（CED）是一种免疫介导的肠球病，并且在特定的触发器中是已知的：麸质。目前的治疗主干是无麸质饮食（GFD）。随着正在开发的新疗法，还研究了互补策略，例如肠道微生物组的调节。肠道微生物群参与了几种慢性疾病中肠炎的启动和永久性。与健康受试者相比，CED患者患者，未经治疗或治疗的CED患者，未经治疗或治疗。几项研究鉴定了与CED患者和健康受试者相关的差异细菌群体。然而，如果肠道缺陷是CED的原因或效果，仍然尚不清楚。益生菌也被认为是调节肠道微生物组到抗炎状态的策略。但是，有一个缺乏数据来支持他们在治疗CED的使用。通过治疗微生物配方需要进一步的研究，所述微生物配方与人类试验结合使用益生菌来治疗通过将肠道微生物组恢复到抗炎状态。
Richa Chibbar;Levinus A. Dieleman[ [*]. The Gut Microbiota in Celiac Disease and probiotics[J]. Nutrients, 2019,11(10): 2375