摘要
Immaturity in digestive-tract motor function and altered intestinal microbiome may play roles in pathogenesis of infantile colic. We assessed the impact of probiotic therapy on crying duration day, in newborns experiencing colic attacks. The PubMed, Embase, Cinnahl, Web of Science databases, and a clinical trials registry (ClinicalTrials.gov) were searched from inception until 12/02/2020. Random-effects meta-analyses were used to derive standardized mean differences/differences in means and risk ratios. We included 16 studies, which involved 1319 newborns aged up to 6 months. Lactobacillus reuteri strain DSM17938 was administered predominantly (n = 10). Probiotic intervention reduced the duration of crying (standardized mean difference = −2.012, 95% confidence interval: −2.763 to −1.261, z = −5.25, p < 0.0001). The probability of at least a 50% reduction in crying duration was at least 1.98 times higher in the intervention group than in controls (Z = 4.80, p < 0.0001). The effects of the intervention were not significantly affected by the risk of bias assessment, percentage of breastfed infants, and duration of the study. In 11 studies, data concerning gut microbiota composition and function and/or immunological markers were given. Probiotics significantly shortened the crying duration, but a causal relationship between the modulatory effect of probiotics on microbiota and the immune system has not been confirmed.
摘要译文
消化道运动功能和改变的肠道微生物组中的不成熟可能在婴儿绞痛的发病机制中发挥作用。我们评估了益生菌治疗对哭泣持续时间的影响，在经历梭菌袭击的新生儿中。在开始到12/02/2020，在开始期待中搜查了PubMed，Embase，Cinnahl，科学数据库和临床试验登记处（Clinicaltrials.gov）。随机效应Meta-Analys用于导出标准化平均差异/差异的手段和风险比率。我们包括16项研究，涉及1319名新生儿，年龄在6个月。乳酸杆菌菌株DSM17938主要施用（n = 10）。益生菌干预降低了静静脉的持续时间（标准化平均差= -2.012,95％置信区间：-2.763至-1.261，Z = -5.25，P <0.0001）。干预持续时间至少减少50％的概率比对照组的至少1.98倍（Z = 4.80，P <0.0001）。干预的影响不会显着影响偏见评估，母乳喂养婴儿百分比和研究持续时间的显着影响。在11项研究中，给出了关于肠道微生物A组成和功能和/或免疫标记的数据。益生菌明显缩短了哭泣的持续时间，但益生菌对微生物群和免疫系统的调节作用之间的因果关系尚未得到证实。
Karolina Skonieczna-Żydecka[ 1]; Katarzyna Janda[ 1]; Mariusz Kaczmarczyk[ 2]; Wojciech Marlicz[ 3]; Igor Łoniewski[ 1];Beata Łoniewska[ 4;[*]. The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials[J]. Journal of Clinical Medicine, 2020,9(4): 999