摘要
Allergies are an increasing global public health concern, especially for children and people living in urban environments. Allergies impair the quality of life of those who suffer from them, and for this reason, alternatives for the treatment of allergic diseases or reduction in their symptoms are being sought. The main objective of this study was to compile the studies carried out on probiotics as a possible therapy for allergies. The most studied allergies on which probiotics have been shown to have a beneficial effect are rhinitis, asthma, and atopic dermatitis. Most studies have studied the administration of Lactobacillus and Bifidobacterium spp. in children and have shown beneficial effects, such as a reduction in hyperreactivity and inflammation caused by allergens and a decrease in cytokine release, among other beneficial effects. In the case of children, no clear beneficial effects were found in several studies, and the potential risk from the use of some opportunistic bacteria, such as probiotics, seems controversial. In the studies that reported beneficial results, these effects were found to make allergy symptoms less aggressive, thus reducing morbidity in allergy sufferers. The different effects of the same probiotic bacteria on different patients seem to reinforce the idea that the efficacy of probiotics is dependent on the microbial species or strain, its derived metabolites and byproducts, and the gut microbiota eubiosis of the patient. This study is relevant in the context of allergic diseases, as it provides a broader understanding of new alternatives for the treatment of allergies, both in children, who are the main sufferers, and adults, showing that probiotics, in some cases, reduce the symptoms and severity of such diseases.
摘要译文
过敏是一个日益增加的全球公共卫生问题，特别是对儿童和生活在城市环境。过敏损害那些谁从他们受苦的生活质量，并为这个原因，正在寻求对过敏性疾病或减少其症状的治疗方案。这项研究的主要目的是收集为过敏的可能治疗益生菌进行的研究。上益生菌已被证明具有有益效果的研究最多的过敏性鼻炎，哮喘和过敏性皮炎。大多数研究都研究了乳杆菌和双歧杆菌的管理。在儿童和已经显示的有益效果，如在高反应性引起的过敏原炎症的降低和细胞因子释放的减少，以及其他有益的效果。在孩子的情况下，在一些研究中没有发现明显的有利影响，以及使用一些机会致病菌的潜在风险，如益生菌，似乎争议。在该报道的有利结果的研究，发现这些效果，使过敏症状较少攻击性，从而减少过敏症患者的发病率。在不同的患者在同一益生菌的不同影响似乎为了强调，益生菌的功效取决于微生物物种或菌株，其衍生的代谢物和副产品，以及患者的肠道菌群eubiosis。这项研究是在过敏性疾病的情况下相关的，因为它提供的用于治疗过敏的新方案更广泛的理解，无论是在儿童，谁是主要的受害者，和成年人，表明益生菌，在某些情况下，减轻症状和这些疾病的严重程度。
Aroa Lopez-Santamarina; Esther Gonzalez Gonzalez; Alexandre Lamas; Alicia del Carmen Mondragon; Patricia Regal;Jose Manuel Miranda[ [*]. Probiotics as a Possible Strategy for the Prevention and Treatment of Allergies. A Narrative Review[J]. Foods, 2021,10(4): 701