期刊文献

Probiotics in Irritable Bowel Syndrome: An Up-to-Date Systematic Review 收藏

肠易激综合征的益生菌：最新的系统评论

原文求助发布源

作者

Hanna Fjeldheim Dale[ 1;2;3;[*]; Stella Hellgren Rasmussen[ 1]; Özgün Ömer Asiller[ 1;4];Gülen Arslan Lied[ 1;2;3]

作者单位

[1] Centre for Nutrition, Department of Clinical Medicine, University of Bergen, 5009 Bergen, Norway [2] Division of Gastroenterology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway [3] National Centre of Functional Gastrointestinal Disorders, Haukeland University Hospital, 5021 Bergen, Norway [4] Department of Gastroenterology, Ankara University Faculty of Medicine, Mamak Ankara 06620, Turkey [*] Author to whom correspondence should be addressed. Nutrients 2019, 11(9), 2048; https://doi.org/10.3390/nu11092048

关键词

irritable bowel syndrome; probiotics; gut microbiota

关键词译文

肠易激综合症;益生菌; gut microbiota.

发布日期

2019-09-02

页码

2048

DOI

10.3390/nu11092048

来源信息

Nutrients ISSN：2072-6643, 2019年, 11卷, 9期, 2048页

摘要

Irritable bowel syndrome (IBS) is a frequent functional gastrointestinal disorder, and alterations in the gut microbiota composition contributes to symptom generation. The exact mechanisms of probiotics in the human body are not fully understood, but probiotic supplements are thought to improve IBS symptoms through manipulation of the gut microbiota. The aim of this systematic review was to assess the latest randomized controlled trials (RCTs) evaluating the effect of probiotic supplementation on symptoms in IBS patients. A literature search was conducted in Medline (PubMed) until March 2019. RCTs published within the last five years evaluating effects of probiotic supplements on IBS symptoms were eligible. The search identified in total 35 studies, of which 11 met the inclusion criteria and were included in the systematic review. Seven studies (63.6%) reported that supplementation with probiotics in IBS patients significantly improved symptoms compared to placebo, whereas the remaining four studies (36.4%) did not report any significant improvement in symptoms after probiotic supplementation. Of note, three studies evaluated the effect of a mono-strain supplement, whereas the remaining eight trials used a multi-strain probiotic. Overall, the beneficial effects were more distinct in the trials using multi-strain supplements with an intervention of 8 weeks or more, suggesting that multi-strain probiotics supplemented over a period of time have the potential to improve IBS symptoms.

摘要译文

肠易激综合征（IBS）是常用的功能性胃肠疾病，肠道微生物群组合物的改变有助于症状产生。益生菌在人体中的确切机制尚不完全明白，但潜水补充剂是通过操纵肠道微生物的操纵来改善IBS症状。该系统审查的目的是评估最新的随机对照试验（RCT）评估益生菌补充对IBS患者症状的影响。在Medline（Pubmed）中进行了文学搜索，直到2019年3月。RCT在过去五年内发表的益生菌补充剂对IBS症状的影响有资格。总共35项研究中确定的搜索，其中11符合纳入标准，并包括在系统审查中。七项研究（63.6％）报告说，与安慰剂相比，IBS患者益生菌的补充显着改善症状，而剩余的四项研究（36.4％）未报告益生菌补充后症状的任何显着改善。值得注意的是，三项研究评估了单菌株补充剂的作用，而剩下的八项试验使用多重菌株益生菌。总体而言，使用多种菌株补充剂的试验中的有益效果更明显，使用8周或更长时间的干预，表明补充了一段时间内的多重菌株益生菌具有改善IBS症状的可能性。

Hanna Fjeldheim Dale[ 1;2;3;[*]; Stella Hellgren Rasmussen[ 1]; Özgün Ömer Asiller[ 1;4];Gülen Arslan Lied[ 1;2;3]. Probiotics in Irritable Bowel Syndrome: An Up-to-Date Systematic Review[J]. Nutrients, 2019,11(9): 2048