摘要
Lactobacilli and bifidobacteria are an important part of human gut microbiota. Among numerous benefits, their antioxidant properties are attracting more and more attention. Multiple in vivo and in vitro studies have demonstrated that lactobacilli and bifidobacteria, along with their cellular components, possess excellent antioxidant capacity, which provides a certain degree of protection to the human body against diseases associated with oxidative stress. Recently, lactobacilli and bifidobacteria have begun to be considered as a new source of natural antioxidants. This review summarizes the current state of research on various antioxidant properties of lactobacilli and bifidobacteria. Special emphasis is given to the mechanisms of antioxidant activity of these bacteria in the human gut microbiota, which involve bacterial cell components and metabolites. This review is also dedicated to the genes involved in the antioxidant properties of lactobacilli and bifidobacteria strains as indicators of their antioxidant potential in human gut microbiota. Identification of the antioxidant biomarkers of the gut microbiota is of great importance both for creating diagnostic systems for assessing oxidative stress and for choosing strategies aimed at restoring the normal functioning of the microbiota and, through it, restoring human health. In this review, the practical application of probiotic strains with proven antioxidant properties to prevent oxidative stress is also considered.
摘要译文
乳杆菌和双歧杆菌是人肠道微生物症的重要组成部分。在许多益处中，它们的抗氧化性能越来越受到关注。体内和体外研究的多重证明，乳酸杆菌和双歧杆菌以及它们的细胞组分具有优异的抗氧化能力，这为人体提供了一定程度的保护，免受氧化应激相关的疾病。最近，乳酸杆菌和双歧杆菌已经开始被视为新的天然抗氧化源。本综述总结了目前对乳杆菌和双歧杆菌的各种抗氧化性质的研究状态。特别强调这些细菌在人体肠道微生物中的抗氧化活性的机制，这涉及细菌细胞成分和代谢物。本综述还致力于参与乳酸杆菌和双歧杆菌菌株的抗氧化性能的基因，作为人体肠道微生物肿瘤中的抗氧化潜力的指标。鉴定肠道微生物瘤的抗氧化生物标志物对于创造用于评估氧化应激的诊断系统以及选择旨在恢复微生物群的正常功能的策略以及恢复人类健康的策略。在本文中，还考虑了益生菌菌株的实际应用，以防止抗氧化性能以防止氧化应激。
Olga V. Averina;Elena U. Poluektova;Mariya V. Marsova;Valery N. Danilenko. Biomarkers and Utility of the Antioxidant Potential of Probiotic Lactobacilli and Bifidobacteria as Representatives of the Human Gut Microbiota[J]. Biomedicines, 2021,9(10): 1340