摘要
The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Alzheimer’s disease (AD), are far from being fully explained. Oxidative stress (OS) has been proposed as one factor that plays a potential role in the pathogenesis of neurodegenerative disorders. Clinical and preclinical studies indicate that neurodegenerative diseases are characterized by higher levels of OS biomarkers and by lower levels of antioxidant defense biomarkers in the brain and peripheral tissues. In this article, we review the current knowledge regarding the involvement of OS in neurodegenerative diseases, based on clinical trials and animal studies. In addition, we analyze the effects of the drug-induced modulation of oxidative balance, and we explore pharmacotherapeutic strategies for OS reduction. KeywordsAlzheimer’s disease Amyotrophic lateral sclerosis Antioxidant defense molecule Non-enzymatic and enzymatic antioxidant Oxidative stress biomarker Parkinson’s disease ESR—electron spin resonance IST—immuno-spin trapping technique
摘要译文
包括肌萎缩性侧索硬化（ALS），帕金森病（PD）和阿尔茨海默病（AD）在内的神经变性疾病的病理生理学远未得到充分解释已经提出氧化应激（OS）作为在神经退行性疾病发病机理中发挥潜在作用的一个因素临床研究表明，神经变性疾病的特征是较高水平的OS生物标志物和较低水平的抗氧化防御生物标志物在脑和外周组织中在本文中，我们基于临床试验和动物研究，回顾了目前关于OS在神经退行性疾病中的参与的知识。另外，我们分析了药物诱导的氧化平衡调节的影响，并且我们探讨了OS减少的药物治疗策略hic侧索硬化抗氧化防御分子非酶和酶促抗氧化氧化应激生物标志物帕金森病ESR电子自旋共振IST免疫自旋捕获技术
Ewa Niedzielska[1];Irena Smaga[1];Maciej Gawlik[1];Andrzej Moniczewski[1];Piotr Stankowicz[1];Joanna Pera[2]. Oxidative Stress in Neurodegenerative Diseases[J]. Molecular Neurobiology, 2016,53(6): 4094–4125