摘要
Glucose is an energy source that also controls the expression of key genes involved in energetic metabolism through the glucose-signaling transcription factor carbohydrate response element-binding protein (ChREBP). ChREBP has recently emerged as a central regulator of glycolysis and de novo fatty acid synthesis in liver, but new evidence shows that it plays a broader and crucial role in various processes, ranging from glucolipotoxicity to apoptosis and/or proliferation in specific cell types. However, several aspects of ChREBP activation by glucose metabolites are currently controversial, as well as the effects of activating or inhibiting ChREBP, on insulin sensitivity, which might depend on genetic, dietary or environmental factors. Thus, much remains to be elucidated. Here, we summarize our current understanding of the regulation and function of this fascinating transcription factor.
摘要译文
葡萄糖是一种能量源还控制通过葡萄糖 - 信令转录因子碳水化合物反应元件结合蛋白（ChREBP基因）参与能量代谢的关键基因的表达。 ChREBP基因最近出现的糖酵解和脂肪酸从头合成在肝脏的中央调节器，但新的证据表明，它在各种处理具有更广泛和重要的作用，从糖脂毒性在特定细胞类型的细胞凋亡和/或增殖。然而，ChREBP基因活化的葡萄糖代谢的几个方面，目前存在争议，以及激活或抑制ChREBP基因，对胰岛素的敏感性，这可能取决于遗传，饮食或环境因素的影响。因此，还有许多工作有待阐明。在这里，我们总结了我们目前的这个迷人的转录因子的调节和功能的理解。
Gaëlle Filhoulaud[1][2][3]; Sandra Guilmeau[1][2][3]; Renaud Dentin[1][2][3]; Jean Girard[1][2][3]; Catherine Postic[1][2][3]. Novel insights into ChREBP regulation and function[J]. Trends in Endocrinology & Metabolism, 2013,24(5): 257-268