摘要
Both cold-acclimated rats and rats at thermoneutrality received 1.5 mg/day of progesterone over a period of 15 days by means of two subcutaneously implanted Silastic capsules. Progesterone treatment increased total food intake and body mass gain in both groups of treated animals when compared with their controls at the same ambient temperature. However, the interscapular brown adipose tissue (BAT) of the treated rats showed the same thermogenic activity (assessed by GDP-binding), mass and gross composition as that of their respective controls. If it is assumed that enhanced food intake is the physiological drive for diet-induced thermogenesis, it could be concluded that progesterone inhibits diet-induced thermogenesis at thermoneutrality, but has no effect in cold-induced thermogenesis. However, if the physiological drive for diet-induced thermogenesis is not enhanced food intake, but an imbalance in the diet, then given that the same diet was offered to all animals thoroughout the experimental period, it could be that progesterone does not affect BAT, either at thermoneutrality or in the cold. Key wordsBrown adipose tissue Cold-induced thermogenesis Diet-induced thermogenesis Progesterone Food intake Body mass gain
摘要译文
两冷驯化大鼠和大鼠thermoneutrality接收孕酮为1g /天一段15天，借助于两个皮下植入硅橡胶胶囊当在相同的环境temperatureHowever与对照组相比，孕激素治疗增加了总的食物摄入量和体重增益处理的动物的这两个群体，肩胛间褐色脂肪组织（BAT）处理过的大鼠显示了相同的产热活动，质量和总组合物为使它们各自的控制（以GDP结合评估）如果假定增强食物摄入为膳食诱导的生热作用的生理驱动器，它可以得出结论，孕酮在thermoneutrality抑制饮食诱导产热，但在冷诱导thermogenesisHowever没有效果，如果为膳食诱导的生热作用的生理驱动器没有增强食物摄取，但在饮食不平衡，然后考虑到相同的饮食是提供给所有的动物thoroughout实验期间，这可能是因为孕酮不影响BAT，无论是在thermoneutrality或在冷重点wordsBrown脂肪组织感冒引起的产热饮食诱导的产热孕酮食品的摄入量体重增
Maria Paz Nava [1] Maria Abelenda [1] Maria Luisa Puerta [1]. Cold-induced and diet-induced thermogenesis in progesterone-treated rats[J]. Pflügers Archiv - European Journal of Physiology, 1990,415(6): 747-750