期刊文献

Role of electrostatic interactions during protein ultrafiltration 收藏

蛋白质超滤过程中静电相互作用的作用
原文求助 发布源
作者
Mahsa M. Rohani; Andrew L. Zydney
作者单位
Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA Available online 14 July 2010
关键词
Ultrafiltration; Electrostatic interactions; Protein; Membrane filtration; Bioseparations
关键词译文
超滤;静电相互作用;蛋白;膜过滤;生物分离
发布日期
14 July 2010
页码
40–48
DOI
10.1016/j.cis.2010.07.002
来源信息
Advances in Colloid and Interface Science ISSN：0001-8686, 2010年, 160卷, 1-2期, 40–48页
摘要
A number of studies over the last decade have clearly demonstrated the importance of electrostatic interactions on the transport of charged proteins through semipermeable ultrafiltration membranes. This paper provides a review of recent developments in this field with a focus on the role of both protein and membrane charge on the rate of protein transport. Experimental results are analyzed using available theoretical models developed from the solution of the Poisson–Boltzmann equation for the partitioning of a charged particle into a charged pore. The potential of exploiting these electrostatic interactions for selective protein separations and for the development of ultrafiltration membranes with enhanced performance characteristics is also examined.
摘要译文
过去十年的一些研究已经清楚地表明了静电相互作用对带电荷蛋白通过半透膜超滤膜的转运的重要性。本文提供了对该领域近期发展的综述，重点是蛋白质和膜电荷的作用关于蛋白质转运率的实验结果使用从泊松 - 奥尔兹曼方程开发的可用理论模型分析实验结果，以将带电粒子分配到带电孔中。利用这些静电相互作用进行选择性蛋白质分离的潜力和对于开发具有增强性能特点的超滤膜也进行了考察
Mahsa M. Rohani; Andrew L. Zydney. Role of electrostatic interactions during protein ultrafiltration[J]. Advances in Colloid and Interface Science, 2010,160(1-2): 40–48