期刊文献

Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitor 收藏

甘草酸DM：抗雄激素破骨细胞发生抑制剂

原文求助发布源

作者

Jie Liu[a]; Jun Shiono[a]; Kuniyoshi Shimizu[a]; Akiko Kukita[b]; Toshio Kukita[c]; Ryuichiro Kondo[a]

作者单位

[a] Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan [b] Faculty of Medicine, Saga University, Nabeshima 5-1-1, Saga 849-8501, Japan [c] Faculty of Dental Science, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan Received 4 December 2008, Revised 16 February 2009, Accepted 27 February 2009, Available online 4 March 2009

关键词

Ganoderma lucidum; Anti-androgen activities; Prostate cancer; Ganoderic acid DM; Androgen receptor; Osteoclast

关键词译文

灵芝抗雄激素活性;前列腺癌;甘草酸DM;雄激素受体;破骨细胞

发布日期

4 March 2009

页码

2154–2157

DOI

10.1016/j.bmcl.2009.02.119

来源信息

Bioorganic & Medicinal Chemistry Letters ISSN：0960-894X, 2009年, 19卷, 8期, 2154–2157页

摘要

Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5α-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis.

摘要译文

前列腺癌是西方国家男性最常见的癌症，骨转移发生率高.Ganoderic酸DM，具有5种α-还原酶抑制和雄激素受体（AR）结合活性，从灵芝乙醇提取物中分离，可以抑制前列腺癌细胞生长并阻断破骨细胞发生

Jie Liu[a]; Jun Shiono[a]; Kuniyoshi Shimizu[a]; Akiko Kukita[b]; Toshio Kukita[c]; Ryuichiro Kondo[a]. Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitor[J]. Bioorganic & Medicinal Chemistry Letters, 2009,19(8): 2154–2157