摘要
Multidrug-resistant bacterial, fungal, viral, and parasitic infections are major health threats. The Infectious Diseases Society of America has expressed concern on the decrease of pharmaceutical companies working on antibiotic research and development. However, small companies, along with academic research institutes, are stepping forward to develop novel therapeutic methods to overcome the present healthcare situation. Among the leading alternatives to current drugs are antimicrobial peptides (AMPs), which are abundantly distributed in nature. AMPs exhibit broad-spectrum activity against a wide variety of bacteria, fungi, viruses, and parasites, and even cancerous cells. They also show potential immunomodulatory properties, and are highly responsive to infectious agents and innate immuno-stimulatory molecules. In recent years, many AMPs have undergone or are undergoing clinical development, and a few are commercially available for topical and other applications. In this review, we outline selected anion and cationic AMPs which are at various stages of development, from preliminary analysis to clinical drug development. Moreover, we also consider current production methods and delivery tools for AMPs, which must be improved for the effective use of these agents.
摘要译文
多重耐药细菌，真菌，病毒和寄生虫感染是主要的健康威胁美国传染病协会已表示对抗生素的研究和developmentHowever，小公司工作药厂的减少表示关切，与学术研究机构一起，挺身而出，为开发新的治疗方法，克服了目前的医疗情况之间的主要替代目前的药物是抗微生物肽（AMPS），其广泛分布在natureAMPs展览广谱活性对多种细菌，真菌，病毒和寄生虫，和甚至癌cellsThey还将显示潜在免疫调节性能，并且是高度响应于传染媒介和先天免疫刺激分子近年来，很多音箱都经历或正在经历临床开发，以及一些市售局部和其他applicationsIn这次审查中，我们概述选择阴离子和阳离子抗菌肽，它们在不同的发展阶段，从初步分析到临床用药developmentMoreover，我们也考虑当前的生产方法和递送工具抗菌肽，必须有效利用这些试剂的改进
Jayaram Lakshmaiah Narayana[a][b]; Jyh-Yih Chen[b]. Antimicrobial peptides: Possible anti-infective agents[J]. Peptides, 2015,72: 88–94