摘要
Objective: 1 – To compare the cycle pregnancy rate of intrauterine insemination (IUI) to that of intrauterine tuboperitoneal insemination (IUTPI) in unexplained infertility. 2 – To assess the effect of timing of insemination in relation to ovulation on the cycle pregnancy rate of IUI and IUTPI. Design: Prospective randomized study. Main outcome measures: 1 – Cycle pregnancy rate of IUI and IUTPI. 2 – Cycle pregnancy rate of preovulatory and postovulatory insemination. Material and methods: Two groups (A and B), each group included 160 women with unexplained primary infertility. Group A were treated by IUI and group B by IUTPI after controlled ovarian stimulation (COS) with sequential clomiphene citrate and human menopausal gonadotropin. Ovulation was by i.m. HCG. At the time of insemination the occurrence of ovulation was checked by transvaginal sonography. Results: After the first treatment cycle 17 patients of group A (10.62%) and 28 patients of group B (17.50%) had ongoing pregnancies (p = 0.0413). After the second treatment cycle 12 patients of group A (8.39%) and 18 patients of group B (19.63%) had ongoing pregnancies (p = 0.0442). After the third treatment cycle 11 patients of group A (8.39%) and 14 patients of group B (12.28%) had ongoing pregnancies (p = 0.0433). After the three treatment cycles 40 patients of group A (25%) and 60 patients of group B (37.50%) had ongoing pregnancies (p = 0.033) and the overall cycle pregnancy rate of group A was 9.21% and group B 14.81% (p = 0.0324). In group A the cycle pregnancy rate of preovulatory insemination was 7.20% and postovulatory 9.76% (p = 0.041). In group B the cycle pregnancy rate of preovulatory insemination was 17.70% and postovulatory 13.0% (p = 0.0322). Five out of 40 pregnancies (12.5%) in group A, and 4 out of 60 pregnancies (6.60%) in group B were twins (p = 0.0431). Conclusion: In unexplained primary infertility IUPI had significantly higher cycle pregnancy rate than IUI. Cycle pregnancy rate of IUI was significantly higher with postovulatory than preovulatory insemination. Cycle pregnancy rate of IUTPI was significantly higher with preovulatory than postovulatory insemination.
摘要译文
目的：1鈥宫内人工授精（IUI）的周期妊娠率比较，在不明原因不孕宫腔内人工授精tuboperitoneal（IUTPI）的2鈥评估人工授精时机的影响相对于对宫腔内人工授精和IUTPIDesign的周期妊娠率排卵：前瞻性随机对照研究主要观察指标：排卵前的人工授精和IUTPI2鈥周期妊娠率1鈥周期妊娠率和排卵后inseminationMaterial和方法：两组（A和B），每个组包括160名不明原因原发性不孕A组是由宫腔内人工授精，B组序贯克罗米芬和人绝经期gonadotropinOvulation通过处理后IUTPI控制卵巢刺激（COS）是由我伫HCG在受精时排卵的发生是检查经阴道sonographyResults：17例B组A组（1025）和28例患者的第一治疗周期后（1750％25）有继续妊娠（P \x3d 03），第二个治疗周期后，A组12例（825）和18例B组（1925）有继续妊娠（P \x3d 02 ）第三个治疗周期后11例B组（1225）的A组（825）和14例患者中有持续的怀孕（P \x3d 03）三个治疗周期后60例组A组（25％25）40例和B（3725）不得不继续妊娠（P \x3d 0）和集团的整体周期妊娠率为921％，25和B组1425（P \x3d 04）A组排卵前人工授精的周期妊娠率为725和925排卵后（P \x3d 0）在B组排卵前人工授精的周期妊娠率为1725和135排卵后（P \x3d 02）五出，A组40怀孕（125），和4，满分60妊娠（660％25），B组是双胞胎（P \x3d 0.01）结论：原因不明的原发性不孕IUPI有显著较高的周期妊娠率比IUIIUI周期妊娠率为显著高于排卵后排卵前相比人工授精IUTPI周期妊娠率为显著高于排卵前排卵后比人工授精
Dina Gamal Eldeen Y. Elkholi[a]; Halah Mohamed Nagy[b]. The impact of timing of insemination in relation to ovulation on the cycle pregnancy rate of intrauterine insemination and intrauterine tuboperitoneal insemination in unexplained infertility[J]. Middle East Fertility Society Journal, 2016,21(1): 4–10