图书章节

The Molecular Slipping in the Redox-Driven H+ Pumps 收藏

氧化还原驱动的H +泵中的分子滑动

原文求助发布源

作者

Giovanni F. Azzone[1];Daniela Pietrobon[1];Dieter Walz[2]

作者单位

[1]C.N.R. Center for the Study of Physiology of Mitochondria and Institute of General PathologyUniversity of PadovaItaly;[2]BiozentrumUniversity of BaselSwitzerland

关键词

Electrochemical Gradient ;Static Head ;Respiratory Control Ratio ;Respiratory Inhibitor ;Leak Conductance

关键词译文

电化学梯度;静压头;呼吸控制比;呼吸抑制剂;泄漏电导率

页码

187-194

DOI

10.1007/978-1-4615-9281-5_15

来源信息

Structure and Function Relationships in Biochemical Systems ISBN：9781461592839, 1982年, 187-194页

摘要

In mammalian mitochondria, as well as in bacteria, respiration is coupled to H⁺ ion extrusion due to operation of the redox-driven H⁺ pumps. This leads^1,2 to formation of a H⁺ electrochemical gradient, Δμ̃_H. Two rates of respiration are distinguished, that of fully uncoupled mitochondria and that of coupled mitochondria in the stationary state, denoted as state 4 or static head. In uncoupled mitochondria the respiratory rate J_e is limited purely by the kinetics of e^- transfer in the respiratory chain. On the other hand in coupled mitochondria the respiratory rate in static head, J _e ^sh , is limited partly by the kinetics of e^- transfer and partly by the thermodynamics of the H⁺ pump (energetic control). The nature of the energetic control requires some clarification.

摘要译文

在哺乳动物线粒体以及细菌中，由于氧化还原驱动的H ^{+ 泵的操作，呼吸与H ^{+ 离子挤出相结合。这导致^{1,2 形成H ^{+ 电化学梯度，ΔμH。两种呼吸速率被区分，即完全未偶联的线粒体和在静止状态下耦合的线粒体的呼吸速率，表示为状态4或静态头部。在未偶联的线粒体中，呼吸速率J e仅受呼吸链中e ^{- 转移动力学的限制。另一方面，在耦合线粒体中，静态头部的呼吸速率J e ^{sh 部分地受到e ^{- 转移的动力学的限制，部分地受到H的热力学的限制。 ^{+ pump（能量控制）。能量控制的性质需要一些澄清。}}}}}}}}

Giovanni F. Azzone[1];Daniela Pietrobon[1];Dieter Walz[2]. The Molecular Slipping in the Redox-Driven H+ Pumps. Structure and Function Relationships in Biochemical Systems[M].DE: Springer, 1982: 187-194