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Localization of Androgen Receptors in Rat Testis: Biochemical Studies 收藏

雄激素受体在大鼠睾丸中的定位：生化研究
原文求助 发布源
作者
Elizabeth M. Wilson[1];Albert A. Smith[1]
作者单位
[1]Departments of Pediatrics and BiochemistryUniversity of North Carolina, School of MedicineChapel HillUSA
关键词
Germ Cell ;Androgen Receptor ;Sertoli Cell ;Interstitial Cell ;Glycol Methacrylate
关键词译文
生殖细胞;雄激素受体;支持细胞;间质细胞;甲基丙烯酸乙二醇酯
页码
281-286
DOI
10.1007/978-1-4613-4440-7_19
来源信息
Hormonal Regulation of Spermatogenesis ISBN：9781461344421, 1975年, 281-286页
摘要
Rat testis has been shown to contain an intracellular receptor protein for testosterone and 5α-dihydrotestosterone (1–5) which is thought to mediate the androgenic stimulus to spermatogenesis. Further identification of the androgen receptor within specific testicular cell types has proved difficult due to their heterogeneity. Localization of receptors in germ cells and/or supporting cells would help establish the mechanism of androgen action in spermatogenesis. In this report, we have measured receptor concentrations in isolated tubules, in a germ cell-free testis obtained from prenatally irradiated rats, and in nonirradiated controls. The data suggest that the androgen receptor is present both in germ cells, interstitial and Sertoli cells.
摘要译文
已显示大鼠睾丸含有睾酮和5α-二氢睾酮（1-5）的细胞内受体蛋白，其被认为介导对精子发生的雄激素刺激。由于它们的异质性，已经证明在特定睾丸细胞类型内进一步鉴定雄激素受体是困难的。生殖细胞和/或支持细胞中受体的定位将有助于建立精子发生中雄激素作用的机制。在本报告中，我们测量了分离小管中的受体浓度，在从产前照射的大鼠和未照射的对照中获得的无生殖细胞的睾丸中。数据表明雄激素受体存在于生殖细胞，间质细胞和支持细胞中。
Elizabeth M. Wilson[1];Albert A. Smith[1]. Localization of Androgen Receptors in Rat Testis: Biochemical Studies. Hormonal Regulation of Spermatogenesis[M].DE: Springer, 1975: 281-286