摘要
Viruses belonging to the newly defined Hantavirus genus in the family Bunyaviridae possess a segmented (tripartite), single-stranded RNA genome of negative polarity. Each RNA segment has a conserved 3′ terminal nucleotide sequence (3′AUCAUCAUCUG), which differs from the consensus sequences reported for the four established genera of Bunyaviridae [1]. These viruses cause hemorrhagic fever with renal syndrome (HFRS) or muroid virus nephropathy, an acute interstitial nephropathy that varies greatly in clinical severity. The severe form of disease, caused by Hantaan virus, the prototype virus of HFRS, is characterized by high fever, renal failure, and varying Suffix of hemorrhage [2]. A milder form of disease, typically without hemorrhage, called nephropathia epidemica, is caused by Puumala virus. Though occasionally severe, infections caused by strains of Seoul virus isolated from peridomestic rats in urban centers of Far Eastern Asia, are usually mild, simulating a flu-like illness with pyrexia, myalgia, flank pain, headache, and proteinuria, with minimal or no hemorrhagic manifestations.
摘要译文
属于布尼亚病毒科中新定义的汉坦病毒属的病毒具有负极性的分段（三部分）单链RNA基因组。每个RNA区段具有保守的3'末端核苷酸序列（3'AUCAUCAUCUG），其不同于报道的布尼亚病毒科的四个确定属的共有序列[1]。这些病毒引起肾综合征出血热（HFRS）或类病毒性肾病，即临床严重程度差异很大的急性间质性肾病。汉坦病毒（HFRS的原型病毒）引起的严重疾病的特征是高热，肾功能衰竭和出血的后缀不同[2]。一种较轻微的疾病，通常没有出血，称为肾病流行病，是由普马拉病毒引起的。虽然偶尔会发生严重的感染，但在远东亚洲城市中心分离出的首尔病毒菌株引起的感染通常是轻微的，模拟了一种类似流感的疾病，伴有发热，肌痛，腰痛，头痛和蛋白尿，极少或根本没有出血表现。
Richard Yanagihara;D. Carleton Gajdusek. Hantavirus Infection: A Newly Recognized Viral Enzootic of Commensal and Wild Rodents in the United States. Concepts in Viral Pathogenesis III[M].DE: Springer, 1989: 291-296