摘要
Open in new tabDownload slideOpen in new tabDownload slideThe effect of non-steroidal anti-inflammatory drugs (NSAID), mostly used for postoperative analgesic purposes for wound healing, is still a matter of debate. Our goal was to evaluate the effects of the most widely used NSAID and corticosteroids after surgical operations on tracheal wound healing in an experimental rat model.Thirty-nine male Wistar albino rats were included in this study. Tracheotomy was performed in 32 rats; then they were divided into 3 groups. After the first day, the animals in group 1 were treated with an NSAID (diclofenac 10 mg/kg/day) (NSAID, n = 12) for 7 days; the animals in group 2 were treated with a corticosteroid (dexamethasone, 2 × 0.1 mg/kg/day) (steroid, n = 10) for 7 days; the animals in group 3 (control, n = 10) were not given any medications. For a fourth group (histological control, n = 7), in order to evaluate normal morphological and histological characteristics, neither surgery nor medication was used. Five rats were eliminated from the study (2 rats in the NSAID group died and 3 rats in the steroid group developed local wound infections). The drop-out rate was 12.8%. Histological characteristics, inflammation, fibrosis, necrosis, neochondrogenesis, neovascularization and epithelization were evaluated in 34 rats. Non-parametric tests were used for statistical analysis.Inflammation, vascularization and number of fibroblasts and chondrocytes were significantly higher in the control group than in the histological control group. There was some reduction in all parameters except vascularization in the NSAID group (P > 0.05). When the steroid group was compared to the NSAID group, inflammation (P < 0.05), vascularization and number of chondrocytes (P > 0.05) were more suppressed in the steroid group. The number of fibroblasts increased in the steroid group (P > 0.05).Steroids and NSAID may have negative effects on tracheal wound healing, probably by suppressing inflammation and fibroblast proliferation. NSAID was mostly used postoperatively for analgesic purposes and should be avoided.
摘要译文
在非甾体类抗炎药（NSAID）的作用（主要用于术后止痛目的以用于伤口愈合）的作用仍是争论的焦点。我们的目标是评估实验大鼠模型中手术后使用最广泛的NSAID和皮质类固醇对气管伤口愈合的影响。本研究包括了39只Wistar白化病雄性大鼠。在32只大鼠中进行气管切开术；然后将它们分为3组。第一天后，将第1组的动物用NSAID（双氯芬酸10μg/ kg /天）（NSAID，n = 12）治疗7天。第2组动物分别给予皮质类固醇（地塞米松，2×0.1 mg / kg / day）（类固醇，n = 10）治疗7天。第3组动物（对照组，n = 10）未给予任何药物治疗。对于第四组（组织学对照，n = 7），为了评估正常的形态学和组织学特征，未使用手术或药物治疗。从研究中剔除五只大鼠（NSAID组中的2只大鼠死亡，类固醇组中的3只大鼠出现局部伤口感染）。辍学率为12.8％。在34只大鼠中评估了组织学特征，炎症，纤维化，坏死，新软骨形成，新血管形成和上皮形成。采用非参数检验进行统计分析。对照组的炎症，血管生成以及成纤维细胞和软骨细胞的数量显着高于组织学对照组。 NSAID组除血管化外所有参数均降低（P> 0.05）。与非甾体类抗炎药组比较，类固醇组的炎症（P <0.05），血管形成和软骨细胞数量（P> 0.05）得到了抑制。类固醇组成纤维细胞数目增加（P> 0.05）。类固醇和非甾体抗炎药可能通过抑制炎症和成纤维细胞增殖而对气管伤口愈合产生负面影响。 NSAID通常在术后用于止痛目的，应避免使用。
Elif Duman[1];Kenan Can Ceylan[2];Deniz Akpınar[3];Nur Yücel[4];Şaban ünsal[2];Soner Duman[5];Şeyda Örs Kaya[2]. The effects of steroidal and non-steroidal anti-inflammatory drugs on tracheal wound healing in an experimental rat model[J]. Interactive CardioVascular and Thoracic Surgery, 2020,30(4): 646-651