摘要
Donor intrauterine insemination with washed spermatozoa (fresh semen) was performed in 36 women (63 cycles) whose husbands had azoospermia due to primary or secondary testicular failure. Simultaneously a control group of 76 couples (156 cycles) with proven fertility, who had recently discontinued mechanical non-hormonal contraception, were encouraged to have sexual intercourse during the fertile period. The age of the women was similar in both groups and the timing criteria were also similar. The pregnancy rate per woman was 50% in the donor insemination group and 47.4% in the control group (difference not significant). The pregnancy rate per cycle was 28.6% in the artificial insemination group and 23.1% in the control, natural insemination group (difference not significant). The number of artificial or natural insemination cycles required to achieve pregnancy was similar in the study and control groups. This study suggests that when the inseminating spermatozoa and female partner are normal, as occurs in the donor insemination group, intrauterine insemination is as efficient as natural insemination in achieving pregnancy but is not more successful.
摘要译文
36名妇女（63个周期）进行了经精子洗净的供体子宫授精，其丈夫因原发性或继发性睾丸衰竭而无精子症。同时，鼓励一组76对已证实具有生育力的夫妇（156个周期），最近已停止机械性非激素避孕，并在生育期进行性交。两组的妇女年龄相似，计时标准也相似。供体受精组每名妇女的怀孕率为50％，对照组为47.4％（差异不显着）。人工受精组每个周期的妊娠率为28.6％，对照组和自然受精组为23.1％（差异不显着）。在研究组和对照组中，达到妊娠所需的人工或自然授精周期数相似。这项研究表明，当授精精子和雌性伴侣正常时（如在供体授精组中一样），宫内授精与自然授精在达到妊娠方面一样有效，但效果不佳。
A.I. Mackenna[1];F. Zegers-Hochschild[1];E.O. Fernandez[1];C.V. Fabres[1];C.A. Huidobro[1];A.R. Guadarrama[1]. Intrauterine insemination: critical analysis of a therapeutic procedure[J]. Human Reproduction, 1992,7(3): 351-354