期刊文献

Inflammation in muscular dystrophy and the beneficial effects of non-steroidal anti-inflammatory drugs 收藏

炎症肌肉萎缩症和非甾体抗炎药的有益效果
原文求助 发布源
作者
Filippo Serra MS[1,†]; Marco Quarta PhD[2,3,†]; Marta Canato PhD[4]; Luana Toniolo PhD[4]; Valeria De Arcangelis PhD[1]; Attilio Trotta MS[1]; Lucia Spath PhD[1]; Lucia Monaco PhD[5]; Carlo Reggiani MD[3,4]; Fabio Naro MD, PhD[1,3,*]
作者单位
[1] DAHFMO Unit of Histology and Medical Embryology, Sapienza University, Via A. Scarpa 14-00161 Rome, Italy [2] Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, Stanford, California, USA [3] IIM, Interuniversity Institute of Myology, Rome, Italy [4] Department of Human Anatomy and Physiology, Biophysics Muscle Laboratory, University of Padua, Padua, Italy [5] Department of Physiology and Pharmacology, Sapienza University, Rome, Italy
关键词
COX; glucocorticoids; inflammation; muscular dystrophy; non-steroidal anti-inflammatory drugs
关键词译文
COX;糖皮质激素;炎症;肌营养不良症;非甾体抗炎药
发布日期
November 2012
页码
773-784
DOI
10.1002/mus.23432
来源信息
Muscle & Nerve ISSN：0148-639X, 2012年, 46卷, 5期, 773-784页
摘要
Introduction: Glucocorticoids are the only drugs available for the treatment of Duchenne muscular dystrophy (DMD), but it is unclear whether their efficacy is dependent on their anti-inflammatory activity. Methods: To address this issue, mdx mice were treated daily with methylprednisolone and non-steroidal anti-inflammatory drugs (NSAIDs: aspirin, ibuprofen, parecoxib). Results: NSAID treatment was effective in ameliorating muscle morphology and reducing macrophage infiltration and necrosis. The percentage of regenerating myofibers was not modified by the treatments. The drugs were effective in reducing COX-2 expression and inflammatory cytokines, but they did not affect utrophin levels. The effects of the treatments on contractile performance were analyzed. Isometric tension did not differ in treated and untreated muscle, but the resistance to fatigue was decreased by treatment with methylprednisolone and aspirin. Conclusions: NSAIDs have a beneficial effect on mdx muscle morphology, pointing to a crucial role of inflammation in the progression of DMD. Muscle Nerve, 2012
摘要译文
引言：糖皮质激素是唯一的药物可用于对杜氏肌营养不良症的治疗（DMD）但目前还不清楚其功效是否依赖于它们的抗炎活性。方法：为了解决这个问题，MDX小鼠用甲泼尼龙和非类固醇消炎药的每日处理（NSAIDs的：阿司匹林，布洛芬，帕瑞考昔）。结果：NSAID治疗能有效改善肌肉形态，减少巨噬细胞浸润，坏死。再生肌纤维的比例不是由处理改性。该药物是有效地减少COX-2的表达和炎性细胞因子，但他们并没有影响的utrophin水平。对收缩性能的处理的效果进行了分析。等长张力没有差异在处理和未处理的肌肉，但是疲劳的电阻下降了甲泼尼龙和阿司匹林治疗。结论：NSAIDs的对肌肉的mdx形态产生有利的影响，指着炎症在DMD的进展中的关键作用。肌肉神经，2012
Filippo Serra MS[1,†]; Marco Quarta PhD[2,3,†]; Marta Canato PhD[4]; Luana Toniolo PhD[4]; Valeria De Arcangelis PhD[1]; Attilio Trotta MS[1]; Lucia Spath PhD[1]; Lucia Monaco PhD[5]; Carlo Reggiani MD[3,4]; Fabio Naro MD, PhD[1,3,*]. Inflammation in muscular dystrophy and the beneficial effects of non-steroidal anti-inflammatory drugs[J]. Muscle & Nerve, 2012,46(5): 773-784