摘要
Proteins are of crucial importance in all biologic organisms, in terms of both structure and function. Their deficits play central roles in many pathologic states, and their potential as powerful therapeutic agents has been widely recognized. Many issues, however, exist in delivery of biologically active proteins to target tissues and organs. Recent advances in biomedical engineering have lead to development of advanced techniques for controlled delivery of peptides and proteins, paving the way for their efficient use in treating human injury and disease. With a particular emphasis on most recent advances, this review discusses currently available techniques for controlled delivery of proteins and considers future research directions.
摘要译文
就结构和功能而言，蛋白质在所有生物有机体中都至关重要。它们的缺陷在许多病理状态中起着核心作用，它们作为强大治疗剂的潜力已得到广泛认可。然而，在将生物活性蛋白递送至靶组织和器官中存在许多问题。生物医学工程学的最新进展已导致控制肽和蛋白质的可控递送的先进技术的发展，为有效地用于治疗人类伤害和疾病铺平了道路。本文特别关注最新进展，讨论了目前可控的蛋白质递送技术，并考虑了未来的研究方向。
Serge Kobsa;W Mark Saltzman. Bioengineering Approaches to Controlled Protein Delivery[J]. Pediatric Research, 2008,63(5): 513-519