摘要
Male infertility is becoming a rapidly growing problem around the world, mainly in the highly developed countries. Seminal proteome composition seems to be one of the crucial factors of the proper course of fertilization ‐ clusterin (CLU) is among the most important ones. CLU, as one of the crucial seminal plasma glycoproteins, plays a very important role in sperm capacitation and immune tolerance in the female reproductive tract. CLU is also known as a sensitive marker of oxidative stress. It has six n ‐glycosylation sites and also exhibits chaperone activity. An analysis of changes in the profile and degree of CLU glycosylation may shed some new light on the molecular mechanisms of the fertilization process and may be used as an additional diagnostic marker of male fertility. This study constitutes a review of the recently available literature concerning human seminal CLU, including changes in its glycosylation, analyzed in the context of human reproduction.
摘要译文
男性不育症正在世界范围内迅速发展，主要是在高度发达国家。精子蛋白质组组成似乎是正确受精过程的关键因素之一。簇蛋白（CLU）是最重要的因素之一。 CLU作为重要的精浆血浆糖蛋白之一，在女性生殖道的精子获能和免疫耐受中起着非常重要的作用。 CLU也被称为氧化应激的敏感标记。它具有六个n糖基化位点，还具有伴侣活性。对CLU糖基化的特征和程度的变化进行的分析可能为受精过程的分子机制提供一些新的启示，并可以用作雄性育性的附加诊断标志。这项研究构成了有关人类精液CLU的最新文献综述，包括在人类生殖环境中分析的其糖基化变化。
Ewa Janiszewska[1];Ewa Maria Kratz[1]. Could the glycosylation analysis of seminal plasma clusterin become a novel male infertility biomarker?[J]. Molecular Reproduction and Development, 2020,87(5): 515-524