摘要
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by inattention, impulsivity and hyperactivity. The etiology of the disorder is multi-factorial, with a main focus on genetic factors. However, emerging research shows the involvement of changes and imbalances in the intestinal microbiota. Evidence for the influence of gut microbiota on brain development and neurogenesis is clear.We present a review of emerging research on the microbiota in the ADHD population. The aim of this study was to summarize the current state of knowledge on ADHD, to identify gaps in knowledge, as well as to indicate the directions of new research. Thanks to the researchers that would be possible to better understand the complexity of ADHD etiology, especially the role of the intestinal microbiota in the pathogenesis of the disorder. Pubmed, Scopus and Google Scholar databases were used while writing the review.Numerous studies show that probiotic supplementation can have a positive effect on the course of neurodevelopmental disorders, including ADHD. Unfortunately, clinical studies that were identified are mostly inconclusive, and more high-quality research is needed to produce robust evidence for therapy based on interventions targeting microbiota.
摘要译文
注意缺陷多动障碍（ADHD）是一种以注意力不集中，冲动和活动亢进为特征的常见神经发育障碍。疾病的病因是多因素的，主要集中在遗传因素上。但是，新兴的研究表明肠道微生物群中存在变化和不平衡。肠道菌群对大脑发育和神经发生的影响的证据很明确。这项研究的目的是总结关于多动症的知识的现状，确定知识方面的差距，并指出新研究的方向。多亏了研究人员，才有可能更好地了解ADHD病因的复杂性，尤其是肠道菌群在疾病发病机理中的作用。撰写本文时使用了Pubmed，Scopus和Google Scholar数据库。大量研究表明，补充益生菌可以对包括ADHD在内的神经发育障碍的进程产生积极影响。不幸的是，已确定的临床研究大多没有定论，需要更高质量的研究，以针对微生物群的干预措施为治疗提供可靠的证据。
AnnaKalenik;KarolinaKardaśAnnaRahnama;KatarzynaSirojćTomaszWolańczyk;. Gut microbiota and probiotic therapy in ADHD: A review of current knowledge - ScienceDirect[J]. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021,110