摘要
Many studies have identified some abnormalities in gastrointestinal (GI) physiology (e.g., increased intestinal permeability, overall microbiota alterations, and gut infection) in children with autism spectrum disorder (ASD). Furthermore, changes in the intestinal flora may be related to GI and ASD symptom severity. Thus, we decided to systematically review the effects of gut microbial-based interventions on gut microbiota, behavioral symptoms, and GI symptoms in children with ASD. We reviewed current evidence from the Cochrane Library, EBSCO PsycARTICLES, PubMed, Web of Science, and Scope databases up to July 12, 2020. Experimental studies that used gut microbial-based treatments among children with ASD were included. Independent data extraction and quality assessment of studies were conducted according to the PRISMA statement. Finally, we identified 16 articles and found that some interventions (i.e., prebiotic, probiotic, vitamin A supplementation, antibiotics, and fecal microbiota transplantation) could alter the gut microbiota and improve behavioral symptoms and GI symptoms among ASD patients. Our findings highlight that the gut microbiota could be a novel target for ASD patients in the future. However, we only provided suggestive but not conclusive evidence regarding the efficacy of interventions on GI and behavioral symptoms among ASD patients. Additional rigorous trials are needed to evaluate the effects of gut microbial-based treatments and explore potential mechanisms.
摘要译文
许多研究已经发现自闭症谱系障碍（ASD）儿童的胃肠道（GI）生理异常（例如，肠道通透性增加，总体微生物群改变和肠道感染）。此外，肠道菌群的变化可能与GI和ASD症状的严重程度有关。因此，我们决定系统地回顾基于肠道微生物的干预对ASD儿童肠道菌群，行为症状和胃肠道症状的影响。我们回顾了截至2020年7月12日来自Cochrane图书馆，EBSCO PsycARTICLES，PubMed，Web of Science和Scope数据库的最新证据。其中包括对ASD儿童使用肠道微生物治疗的实验研究。根据PRISMA声明进行了独立的数据提取和研究质量评估。最后，我们确定了16篇文章，发现一些干预措施（例如，益生元，益生菌，维生素A补充，抗生素和粪便微生物群移植）可以改变肠道菌群并改善ASD患者的行为症状和胃肠道症状。我们的发现强调，肠道菌群可能会成为ASD患者的新型靶标。但是，我们仅提供有关ASD患者中GI和行为症状干预效果的暗示性而非决定性证据。还需要进行其他严格的试验，以评估基于肠道微生物的治疗的效果并探索潜在的机制。
JiaxinYang[a][b];XiFu[a][b];XiaoliLiao[a];YaminLi[b]. Effects of gut microbial-based treatments on gut microbiota, behavioral symptoms, and gastrointestinal symptoms in children with autism spectrum disorder: A systematic review[J]. Psychiatry Research, 2020,293