摘要
Antibodies (Abs) are emerging as an important class of therapeutic agents for the treatment of various human diseases, often conjugated to drugs or toxic substances. In recent years, the incidence of cancer and infectious diseases has increased dramatically, making it imperative to discover new effective therapeutic molecules. Among these, small peptides are arousing great interest. Synthetic peptides, representative of variable and constant region fragments of Abs, were proved to exert in vitro, ex vivo and/or in vivo anti-microbial, anti-viral, anti-tumour and/or immunomodulatory activities, mediated by different mechanisms of action and regardless of the specificity and isotype of the Ab. Some of these synthetic peptides possess the ability to spontaneously and reversibly self-assemble in an organised network of fibril-like structure. Ab fragments may represent a novel model of targeted anti-infective and anti-tumour auto-delivering drugs.
摘要译文
抗体（Abs）作为一种重要的治疗剂正在兴起，用于治疗各种人类疾病，通常与药物或有毒物质结合。近年来，癌症和传染病的发病率急剧增加，因此必须发现新的有效治疗分子。其中，小肽引起了极大的兴趣。已证明代表Abs可变区和恒定区片段的合成肽在体外，离体和/或体内具有不同的作用机制介导的抗微生物，抗病毒，抗肿瘤和/或免疫调节活性并且不考虑抗体的特异性和同种型。这些合成肽中的某些具有自发和可逆地自组装成原纤维状结构网络的能力。 Ab片段可能代表靶向抗感染和抗肿瘤自动递送药物的新型模型。
Tecla Ciociola; Walter Magliani; Laura Giovati; Martina Sperindè; Claudia Santinoli; Giorgio Conti; Stefania Conti; Luciano Polonelli. Antibodies as an Unlimited Source of Anti-Infective, Anti-Tumour and Immunomodulatory Peptides[J]. Science Progress, 2014,97(3): 215-233