期刊文献

Effect of fermented feed on growth performance, holistic metabolism and fecal microbiota in weanling piglets 收藏

发酵饲料对断奶仔猪生长性能，整体代谢和粪便微生物群的影响

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作者

LinliHuang[a];PingpingRen[a][b];ZichengOuyang[a];TaoWei[a];XiangfengKong[c];TiejunLi[c];YulongYin[b][c];ShanpingHe[b];ChengboYang[d];QinghuaHe[a]

作者单位

[a]Department of Food Science and Engineering, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong 518071, China[b]Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, School of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China[c]Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan 410125, China[d]Department of Animal Science, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg, Manitoba R3T2N2, Canada

关键词

Fermented feed;Fecal;Microbiota;Metabolism;Metabonomics;Weanling piglets;

关键词译文

发酵饲料;粪便;微生物群;代谢;代谢组学;断奶仔猪;

发布日期

1 August 2020

DOI

10.1016/j.anifeedsci.2020.114505

来源信息

Animal Feed Science and Technology ISSN：0377-8401, 2020年, 266卷

摘要

Supplying diet with fermented feed (FF) has great potential to improve gut health and growth performance in weanling piglets. This study was conducted to investigate the effect of FF on growth performance, holistic metabolism and fecal microbiota in weanling piglets, and to explore modulating metabolism and gut health as a possible mechanism. A total of 48 weanling piglets were randomly divided into two treatments with control (CON) diet and FF diet. The results showed that diarrhea rate and feed intake/bodyweight gain ratio were decreased by 40.51% and 7.89% (P < 0.05), respectively, in FF group compared with CON group. The results of biochemical metabolites showed that the concentration of ApoA1 in serum was significantly higher in FF group than that in CON group (P < 0.05). Nuclear magnetic resonance-based metabonomics analysis revealed that increased levels of plasma glycine, trimethylamine, pyruvate and succinate (P < 0.05), whereas decreased level of plasma lactate (P < 0.05) were observed in FF group compared with CON group. Elevated levels of urine leucine, isoleucine, valine and lactate (P < 0.05), while reduced levels of urine trimethylamine oxide, taurine and trans-aconitate (P < 0.05) were observed in FF group related to CON group. Fecal microbiota was altered in FF group, resulting decreased relative abundance of the genus Lactobacillus and increased that of Prevotella in the feces by 16S rRNA gene sequencing. These noval findings provide an evidence for the potential mechanisms that should be the improvement of immunity, holistic metabolism and gut microbiota.

摘要译文

在日粮中添加发酵饲料（FF）具有改善断奶仔猪肠道健康和生长性能的巨大潜力。本研究旨在研究FF对断奶仔猪生长性能，整体代谢和粪便微生物群的影响，并探讨调节代谢和肠道健康的可能机制。将48只断奶仔猪随机分为对照组（CON）和FF组两种。结果表明，与CON组相比，FF组的腹泻率和采食量/体重增加率分别降低了40.51％和7.89％（P <0.05）。生化代谢产物的结果表明，FF组的血清ApoA1浓度明显高于CON组（P <0.05）。基于核磁共振的代谢组学分析表明，与CON组相比，FF组血浆甘氨酸，三甲胺，丙酮酸和琥珀酸盐水平升高（P <0.05），而血浆乳酸水平（P <0.05）降低。与CON组相关的FF组尿中亮氨酸，异亮氨酸，缬氨酸和乳酸水平升高（P <0.05），尿三甲基氧化氮，牛磺酸和反硝酸盐水平降低（P <0.05）。 FF组的粪便菌群发生了变化，通过16S rRNA基因测序，粪便中乳酸菌属的相对丰度降低，粪便中Prevotella的丰度升高。这些新发现为潜在的机制提供了证据，这些机制应该是免疫力，整体代谢和肠道菌群的改善。

LinliHuang[a];PingpingRen[a][b];ZichengOuyang[a];TaoWei[a];XiangfengKong[c];TiejunLi[c];YulongYin[b][c];ShanpingHe[b];ChengboYang[d];QinghuaHe[a]. Effect of fermented feed on growth performance, holistic metabolism and fecal microbiota in weanling piglets[J]. Animal Feed Science and Technology, 2020,266