期刊文献

Impact of Autolysed Brewer’s Yeast and Soluble Dried Yeast Extract on Growth Performance and Mucosal Health of Atlantic Salmon (Salmo salar) Parr 收藏

自动酿造啤酒的酵母和可溶性酵母提取物对大西洋鲑鱼（Salmo Salar）Parr的生长性能和粘膜健康的影响

原文求助发布源

作者

Sheu G. Odu-Onikosi (https://orcid.org/0000-0001-6335-0364) [1];Taofik A. Momoh (https://orcid.org/0000-0002-5798-4640) [2];Sherilyn T. Abarra [3];Noah E. Wood (https://orcid.org/0009-0004-3667-8128) [4];Folasade D. Amulejoye (https://orcid.org/0000-0002-5657-9504) [5];Matthew Emery [6];Glenn M. Harper [7];Benjamin Eynon [8];Victor Kuri (https://orcid.org/0000-0003-1706-7597) [9];Holger Kühlwein [10];Daniel L. Merrifield (https://orcid.org/0000-0002-1790-2217) [11];

作者单位

[1]Fish Health and Nutrition Research Group, School of Biological and Marine Sciences, University of Plymouth, Plymouth PL4 8AA, UK; [2]Fish Health and Nutrition Research Group, School of Biological and Marine Sciences, University of Plymouth, Plymouth PL4 8AA, UK; [3]Fish Health and Nutrition Research Group, School of Biological and Marine Sciences, University of Plymouth, Plymouth PL4 8AA, UK; [4]Fish Health and Nutrition Research Group, School of Biological and Marine Sciences, University of Plymouth, Plymouth PL4 8AA, UK; [5]Department of Fisheries and Aquaculture Technology, Olusegun Agagu University of Science and Technology, P.M.B. 353, Okitipupa 350105, Nigeria; [6]Fish Health and Nutrition Research Group, School of Biological and Marine Sciences, University of Plymouth, Plymouth PL4 8AA, UK; [7]Fish Health and Nutrition Research Group, School of Biological and Marine Sciences, University of Plymouth, Plymouth PL4 8AA, UK; [8]Fish Health and Nutrition Research Group, School of Biological and Marine Sciences, University of Plymouth, Plymouth PL4 8AA, UK; [9]Fish Health and Nutrition Research Group, School of Biological and Marine Sciences, University of Plymouth, Plymouth PL4 8AA, UK; [10]Leiber GmbH, 49565 Bramsche, Germany; [11]Fish Health and Nutrition Research Group, School of Biological and Marine Sciences, University of Plymouth, Plymouth PL4 8AA, UK;

发布日期

2025-1-23

页码

323

DOI

10.3390/ani15030323

来源信息

Animals ISSN：2076-2615, 2025年, 15卷, 3期, 323页

摘要

Yeast-based feed additives have emerged as promising functional feed additives (FFAs) to promote sustainable aquaculture development through enhanced gut health and immune modulation in fish. The present study evaluated the impact of autolysed brewer’s yeast (ABY) and soluble dried yeast extract (SDYE) in improving the intestinal and skin histology, immune response, and intestinal microbiome of Atlantic salmon parr (Salmo salar) over a 9-week feeding trial. Three experimental diets were produced: a control diet, a diet supplemented with ABY at 2.5 g/kg, and a diet supplemented with SDYE at 2.5 g/kg. These diets were administered to triplicate tanks of Atlantic salmon. The yeast-supplemented diets, especially ABY, improved intestinal mucosal fold length, lamina propria width, microvilli density, and intestinal goblet cell counts, as well as skin goblet cell counts. The yeast additives had no detrimental effects on the fish haematology, with no significant differences in haemoglobin concentration, red blood cell counts, and white blood cell counts among the treatment groups. Gene expression analysis revealed upregulation of il-1β and muc-2 in fish fed the ABY diet, indicating enhanced immune function and potentially mucosal protection. Intestinal microbiota analysis revealed Firmicutes as the most dominant phylum in all groups, followed by Actinobacteriota. Distinct bacterial community shifts were observed between the treatment groups, with a significant increase in the relative abundance of taxa such as Staphylococcus in yeast-supplemented diets and a significant decrease in Streptococcus and Weissella. Collectively, these findings suggest that the yeast additives, especially ABY, enhance gut health and immune function without compromising growth performance.

摘要译文

基于酵母的饲料添加剂已成为有前途的功能饲料添加剂（FFA），以通过增强的肠道健康和鱼类的免疫调节来促进可持续的水产养殖开发。本研究评估了自动级别的酿酒酵母（ABY）和可溶性干酵母提取物（SDYE）在一项为期9周的进食试验中，改善了大西洋鲑鱼Parr（Salmo Salar）的肠道和皮肤组织学，免疫反应和肠道微生物组的影响。产生了三种实验饮食：一种对照饮食，一种以2.5 g/kg为单位的ABY饮食，以及以2.5 g/kg的饮食补充的饮食。这些饮食被给予大西洋鲑鱼的一式三份储罐。补充酵母的饮食，尤其是ABY，改善了肠粘膜褶皱长度，固有层宽度，微绒毛密度和肠道杯细胞计数以及皮肤杯状细胞计数。酵母添加剂对鱼类血液学没有不利影响，在治疗组中，血红蛋白浓度，红细胞计数和白细胞计数没有显着差异。基因表达分析表明，在喂养ABY饮食的鱼类中，IL-1β和MUC-2上调，表明免疫功能增强并可能具有粘膜保护。肠道菌群分析表明，富公司是所有组中最优势的门，其次是肌动杆菌。在治疗组之间观察到了不同的细菌群落转移，在酵母菌补充饮食中的葡萄球菌相对丰度显着增加，链球菌和魏森氏菌的显着下降。总的来说，这些发现表明酵母添加剂，尤其是ABY，可以增强肠道健康和免疫功能，而不会损害生长性能。