摘要
The social amoeba Dictyostelium discoideum has long served as a model system for studying fundamental processes in cell and developmental biology. This eukaryotic microbe is also recognized as a model organism for biomedical and human disease research since the genome encodes homologs of genes linked to human disease, such as those linked to cancer and neurodegeneration. Dictyostelium has a unique life cycle composed of a unicellular growth phase and a multicellular developmental phase that is induced by starvation. During its life cycle, Dictyostelium undergoes conserved cellular processes including, but not limited to, cell proliferation, phagocytosis, intercellular signaling, cell adhesion and motility, chemotaxis, and cell differentiation. The history of the organism, the resources available to researchers in the community, and the diverse ways that Dictyostelium is used in the contemporary research lab are discussed. © 2017 by John Wiley & Sons, Inc.
摘要译文
社会变形虫盘基网柄菌（Dictyostelium discoideum）长期以来一直是研究细胞和发育生物学基本过程的模型系统。该真核微生物也被认为是用于生物医学和人类疾病研究的模型生物，因为该基因组编码与人类疾病相关的基因的同源物，例如与癌症和神经变性相关的基因。盘基网柄菌具有独特的生命周期，由单细胞生长期和饥饿诱导的多细胞发育期组成。在其生命周期中，盘基网柄菌经历保守的细胞过程，包括但不限于细胞增殖，吞噬作用，细胞间信号传导，细胞粘附和运动，趋化性和细胞分化。讨论了有机体的历史，社区研究人员可获得的资源，以及当代研究实验室中盘基网柄菌的多种使用方式。 ©2017 John Wiley＆Sons，Inc。
Sabateeshan Mathavarajah[1];Ana Flores[1];Robert J. Huber[1].
Dictyostelium discoideum: A Model System for Cell and Developmental Biology[J]. Current Protocols in Essential Laboratory Techniques, 2017,15(1): 14.1.1-14.1.19