摘要
Macrophages, within the cytokine network, are a major source of many cytokines involved in immune response, hematopoiesis, inflammation and many other homeostatic processes. Upon stimulation by micro-organisms, microbial products or endogenous factors including cytokines, macrophages can de novo synthesize and release a large variety of cytokines (ie IL-1, IL-Ira, IL-6, IL-8, IL-10, IL-12, TNFα, IFNα, IFNy, MCP-l, MCP-3, MIF, M-CSF, G-CSF, GM-CSF, MIP-l, MIP-2, LIF, OSM, TGFβ). Some cytokines can upregulate the production of cytokines by macrophages (IL-3, GM-CSF, IFNγ) while others can inhibit it (IL-4, IL-10, IL-13, TGFβ). In addition, these cytokines can modulate most of the macrophage functions and cell surface marker expression. Other cytokines (the chemokines such as MCP-1,2,3, MIP-1,2 and RANTES) contribute to the recruitment of circulating monocytes within tissues. It is worth noting that macrophages can be their own source of regulatory cytokines.
摘要译文
细胞因子网络内的巨噬细胞是参与免疫应答，造血，炎症和许多其他稳态过程的许多细胞因子的主要来源。在被微生物，微生物产物或内源性因子（包括细胞因子）刺激后，巨噬细胞可以从头合成并释放多种细胞因子（即IL-1，IL-1ra，IL-6，IL-8，IL-10，IL）。 -12，TNFα，IFNα，IFNγ，MCP-1，MCP-3，MIF，M-CSF，G-CSF，GM-CSF，MIP-1，MIP-2，LIF，OSM，TGFβ）。一些细胞因子可以通过巨噬细胞（IL-3，GM-CSF，IFNγ）上调细胞因子的产生，而其他细胞因子可以抑制它（IL-4，IL-10，IL-13，TGFβ）。此外，这些细胞因子可以调节大多数巨噬细胞功能和细胞表面标志物表达。其他细胞因子（趋化因子如MCP-1,2,3，MIP-1,2和RANTES）有助于组织内循环单核细胞的募集。值得注意的是，巨噬细胞可能是它们自身的调节细胞因子来源。