期刊文献

Biomimetic Remineralization Strategies for Dentin Bond Stability—Systematic Review and Network Meta-Analysis 收藏

牙本质债券稳定性的仿生回忆策略 - 系统审查和网络荟萃分析
原文求助 发布源
作者
Rosário Costa (https://orcid.org/0000-0003-1022-6858) [1];Joana Reis-Pardal [2];Sofia Arantes-Oliveira [3];João Cardoso Ferreira [4];Luis Filipe Azevedo (https://orcid.org/0000-0002-8421-2937) [5];Paulo Melo (https://orcid.org/0000-0003-3590-4926) [6];
作者单位
[1]Faculty of Dental Medicine, Department of Operative Dentistry, University of Porto, Rua Dr. Manuel Pereira da Silva, 4200-393 Porto, Portugal; [2]CINTESIS@RISE—Center for Health Technology and Services Research (CINTESIS), Health Research Network Associated Laboratory (RISE), University of Porto, 4200-450 Porto, Portugal; [3]Department of Dental Biomaterials, Faculty of Dental Medicine, University of Lisbon, Cidade Universitária, Rua Prof.ª Teresa Ambrósio, 1600-277 Lisbon, Portugal; [4]Faculty of Dental Medicine, Department of Operative Dentistry, University of Porto, Rua Dr. Manuel Pereira da Silva, 4200-393 Porto, Portugal; [5]CINTESIS@RISE—Center for Health Technology and Services Research (CINTESIS), Health Research Network Associated Laboratory (RISE), University of Porto, 4200-450 Porto, Portugal; [6]Faculty of Dental Medicine, Department of Operative Dentistry, University of Porto, Rua Dr. Manuel Pereira da Silva, 4200-393 Porto, Portugal;
发布日期
2025-4-8
页码
3488
DOI
10.3390/ijms26083488
来源信息
International Journal of Molecular Sciences ISSN：1422-0067, 2025年, 26卷, 8期, 3488页
摘要
This systematic review and network meta-analysis aimed to evaluate the bond strength of artificial caries-affected dentin (ACAD) of permanent human teeth with and without biomimetic remineralization (BR), assessed based on in vitro studies. Following PRISMA guidelines, we conducted a systematic search until June 2023, identifying 82 eligible articles for full-text analysis. We assessed the study characteristics, methodological quality, and summary results. Bond strength was examined immediately and after artificial aging using three bond strength tests. We performed meta-regressions (using OpenBUGS software) to explore the relationship between the independent variable’s adhesive application technique (Etch-and-Rinse or Self-Etch) and ACAD protocol (chemical or biological) and the dependent variable of bond strength. Additionally, we conducted random-effect NMAs (using CINEMA software) to compare the effect of multiple interventions per application technique and ACAD protocol simultaneously. Among the included studies that compared various BR strategies, most studies (19 out of 22) presented a medium risk of bias. In some comparisons, the meta-regression results revealed a significant association between bond strength at 24 h and both the adhesive application technique and the ACAD protocol. Our findings indicate the potential of BR to enhance bond strength in human ACAD in in vitro settings.
摘要译文
这项系统的综述和网络荟萃分析旨在根据体外研究评估，旨在评估具有和不具有仿生型回忆性（BR）的永久性人类牙齿的人造牙本质（ACAD）的键强度。遵循PRISMA指南，我们进行了系统的搜索，直到2023年6月，确定了82条合格的文章以进行全文分析。我们评估了研究特征，方法质量和摘要结果。立即使用三个键强度测试对人工化后立即检查键强度。我们进行了元回归（使用openbugs软件），以探索自变量的粘合剂应用技术（蚀刻或自我自我）与ACAD协议（化学或生物学）（化学或生物学）与键强度变量之间的关系。此外，我们进行了随机效应NMA（使用Cinema软件），以同时比较每个应用技术和ACAD协议的多种干预措施的效果。在比较各种BR策略的纳入研究中，大多数研究（22个中的19个）表现出了中等的偏见风险。在某些比较中，元回归结果表明，键在24小时与粘合剂应用技术和ACAD协议之间存在显着关联。我们的发现表明，BR在体外环境中增强人类学院的纽带强度的潜力。
Rosário Costa (https://orcid.org/0000-0003-1022-6858) [1];Joana Reis-Pardal [2];Sofia Arantes-Oliveira [3];João Cardoso Ferreira [4];Luis Filipe Azevedo (https://orcid.org/0000-0002-8421-2937) [5];Paulo Melo (https://orcid.org/0000-0003-3590-4926) [6];. Biomimetic Remineralization Strategies for Dentin Bond Stability—Systematic Review and Network Meta-Analysis[J]. International Journal of Molecular Sciences, 2025,26(8): 3488