期刊文献

Pharmacokinetic characteristics of florfenicol in green sea turtles (Chelonia mydas) and hawksbill sea turtles (Eretmochelys imbricata) after intramuscular administration 收藏

绿海龟（Chelonia mydas）和Hawksbill海龟（Eretmochelys imbricata）在肌肉内给药后的药代动力学特征
原文求助 发布源
作者
Pandaree Sitthiangkool [1];Amnart Poapolathep (0000-0001-5322-3281) [2];Thanaphan Chomcheun [3];Oranee Jongkolpath [4];Kraisiri Khidkhan [5];Narumol Klangkaew [6];Napasorn Phaochoosak [7];Mario Giorgi (0000-0003-3657-4703) [8];Saranya Poapolathep (0000-0002-5249-903X) [9];
作者单位
[1]Department of Pharmacology, Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand; [2]Department of Pharmacology, Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand; [3]Eastern Marine and Coastal Resources Research and Development Center Rayong Thailand; [4]Eastern Marine and Coastal Resources Research and Development Center Rayong Thailand; [5]Department of Pharmacology, Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand; [6]Department of Pharmacology, Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand; [7]Department of Pharmacology, Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand; [8]Department of Veterinary Sciences University of Pisa San Piero a Grado Italy; [9]Department of Pharmacology, Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand;
发布日期
2024-3-22
页码
300-307
DOI
10.1111/jvp.13441
来源信息
Journal of Veterinary Pharmacology and Therapeutics ISSN：0140-7783, 2024年, 47卷, 4期, 300-307页
摘要
【Abstract】The pharmacokinetics of florfenicol (FFC) in green sea and hawksbill sea turtles were evaluated following intramuscular (i.m.) administration at two different dosages of 20 or 30 mg/kg body weight (b.w.). This study (longitudinal design) used 5 green sea and 5 hawksbill sea turtles for the two dosages. Blood samples were collected at assigned times up to 168 h. FFC plasma samples were analyzed using validated high‐performance liquid chromatography equipped with diode array detection. The pharmacokinetic analysis was performed using a non‐compartment approach. The FFC plasma concentrations increased with the dosage. The elimination half‐life was similar between the treatment groups (range 19–25 h), as well as the plasma protein binding (range 18.59%–20.65%). According to the surrogate PK/PD parameter (T > MIC, 2 μg/mL), the 20 and 30 mg/kg dosing rates should be effective doses for susceptible bacterial infections in green sea and hawksbill sea turtles.
摘要译文
【摘要】在两种不同剂量的20或30 mg/kg体重（B.W.）时，评估了绿海和鹰海龟佛罗里芬酸（FFC）的药代动力学（FFC）。这项研究（纵向设计）用于两种剂量，使用了5个绿海和5枚鹰海龟。在分配的时间内收集血液样本最多168小时。使用配备有二极管阵列检测的经过验证的高性能液相色谱法分析FFC血浆样品。使用非派对方法进行药代动力学分析。FFC血浆浓度随剂量增加。治疗组（范围19-25 h）以及血浆蛋白结合（范围18.59％–20.65％）之间的消除半衰期相似。根据替代PK/PD参数（T> MIC，2μg/mL），20和30 mg/kg的剂量率应有效剂量，用于绿色海洋和鹰海龟的易感细菌感染。
Pandaree Sitthiangkool [1];Amnart Poapolathep (0000-0001-5322-3281) [2];Thanaphan Chomcheun [3];Oranee Jongkolpath [4];Kraisiri Khidkhan [5];Narumol Klangkaew [6];Napasorn Phaochoosak [7];Mario Giorgi (0000-0003-3657-4703) [8];Saranya Poapolathep (0000-0002-5249-903X) [9];. Pharmacokinetic characteristics of florfenicol in green sea turtles (Chelonia mydas) and hawksbill sea turtles (Eretmochelys imbricata) after intramuscular administration[J]. Journal of Veterinary Pharmacology and Therapeutics, 2024,47(4): 300-307