摘要
Hyperoestrogenism causing progressive alopecia in neutered ferrets may be induced by ovarian remnant syndrome (ORS) and nodular hyperplasia of the adrenocortex (hyperadrenocorticism, NHA). The objective of the study was to determine whether a slow-release implant of a gonadotropin releasing hormone (GnRH) analogue, deslorelin, has any value in therapy of hyperoestrogenism of adrenocortical origin (NHA). Three supposed cases of NHA with alopecia and other clinical signs of hyperoestrogenism (n = 2 spayed females in oestrous and n = 1 castrated male) were treated with a subcutaneous implant of 4.7 mg deslorelin acetate. Blood samples were collected, and plasma levels of estradiol (E2) were determined just before, and some weeks after treatment. For realistic monitoring, blood samples for E2 determination were also taken from intact, healthy (untreated control) females after the beginning of heat (n = 5), or 9–21 days after, with hCG induced ovulation (n = 6), or out of breeding season (n = 3). Before treatment, all three alopecic ferrets showed elevated E2 concentrations (99.45–139.9 pmol/l) similar to the untreated control females in oestrous (61.6–123.02 pmol/l) (P = 0.229). Some weeks after the deslorelin administration, the hair of these ferrets began to grow again and the elevated E2 concentrations significantly decreased compared to the pre-treatment values (P = 0.035). E2 concentrations reached the basal level (12.89–16.08 pmol/l) typical for that of the untreated control females in anoestrus or in luteal phase (12.0–30.58 pmol/l) (P = 0.137). All treated ferrets were examined again 19–21 months after implant insertion (the implant still being present) and all of them had normal hair and were clinically healthy. These observations prove that deslorelin can suppress the E2 production of NHA, and is therefore a useful tool in the therapy of hormonal alopecia neutered ferrets.
摘要译文
可能由卵巢残余综合征（ORS）和肾上腺皮质结节性增生（hyperadrenocorticism，NHA）诱导导致绝经雪貂进行性脱发的高雌激素血症。该研究的目的是确定促性腺激素释放激素（GnRH）类似物deslorelin的缓释植入物是否对治疗肾上腺皮质起源（NHA）的过度雌激素有任何价值。用皮下植入4.7mg醋酸地尔瑞林治疗3例假脱象的NHA伴有脱发和其他过度雌激素的临床症状（n = 2只发情的雌性发情和n = 1阉割雄性）。收集血样，并在治疗前和治疗后几周测定雌二醇（E 2）的血浆水平。为了实际监测，在hCG诱导排卵后（n = 6），在开始加热（n = 5）或9-21天之后，还从完整的，健康的（未治疗的对照）雌性中采集用于E 2测定的血液样品，n = 6，或退出繁殖季节（n = 3）。在处理之前，所有三种特异性雪貂都显示出与发情的未处理对照雌性（61.6-123.02pmol / l）相似的E 2浓度升高（99.45-139.9pmol / l）（P = 0.229）。在施用deslorelin几周后，这些雪貂的毛发开始再次生长，并且与治疗前的值相比，升高的E 2浓度显着降低（P = 0.035）。 E2浓度达到基线水平（12.89-16.08pmol / l），通常为未治疗的对照雌性动物在发情期或黄体期（12.0-30.58pmol / l）（P = 0.137）。在植入物插入后19-21个月（植入物仍然存在）再次检查所有处理过的雪貂，并且它们都具有正常的毛发并且具有临床健康。这些观察结果证明，deslorelin可以抑制NHA的E 2产生，因此是治疗荷尔蒙秃痪绝育雪貂的有用工具。
A. Prohaczik; M. Kulcsar; Gy. Huszenicza. Deslorelin treatment of hyperoestrogenism in neutered ferrets (Mustela putorius furo): a case report[J]. Veterinární Medicína, 2009,54(2): 89-95