期刊文献

Effect of Nonionic Surfactans on the Percutaneous Absorption of Tenoxicam 收藏

非离子表面活性剂对偶唑菌垂直吸收的影响
原文求助 发布源
作者
Masayuki ENDO;Takeshi YAMAMOTO;Tomoko IJUIN;[1]
作者单位
[1]著者所属： Pola R & D Laboratories, Pola Corporation Pola R & D Laboratories, Pola Corporation Pola R & D Laboratories, Pola Corporation
关键词
percutaneous absorption;nonionic surfactant;hemolysis;solubility;HLB;Tenoxicam
关键词译文
经皮吸收;非离子表面活性剂;溶血;溶解度; HLB; Tenoxicam
页码
865-867
DOI
10.1248/cpb.44.865
来源信息
Chemical and Pharmaceutical Bulletin ISSN：0009-2363, 1996年, 44卷, 4期, 865-867页
摘要
The effect of 14 types of nonionic surfactants on the permeation of Tenoxicam (TEN) through guinea pigs from propylene glycol solution was investigated in vitro. The flux of TEN was significantly enhanced by polyoxyethylene alkyl ether and polyoxyethylene monoalkyl carboxylate as hydrophilic surfactants, and by polyglyceryl trialkylate, glyceryl monoalkylate, sorbitan monoalkyl carboxylate and sorbitan trialkyl carboxylate as hydrophobic surfactants. In the presence of these surfactants, the flu
摘要译文
体外研究了14种非离子表面活性剂对通过丙二醇溶液中豚鼠渗透的偶毒蛋白（10）的渗透。通过聚氧乙烯烷基烷基醚和聚氧乙烯单烷基作为亲水表面活性剂和聚甘油二烷基酯，甘油单烷基化物，山梨糖醇单烷基羧酸甘油酯和脱水甘露糖醇羧酸甘露糖羧酸酯作为疏水性表面活性剂的聚氧乙烯单烷基，作为疏水性表面活性剂的聚氧乙烯单烷基，以及作为疏水性表面活性剂的聚甘露糖醇。在这些表面活性剂的存在下，流感
Masayuki ENDO;Takeshi YAMAMOTO;Tomoko IJUIN;[1]. Effect of Nonionic Surfactans on the Percutaneous Absorption of Tenoxicam[J]. Chemical and Pharmaceutical Bulletin, 1996,44(4): 865-867