摘要
This study aimed to investigate and study the effectiveness as well as the efficacy of five natural products as alternatives for treating ovarian cysts and to correlate their biological activities with their active constituents. Phyllanthus emblica fruits, Trigonella foenum-graecum seeds, Brassica oleracea flowers, and Persea americana fruits were extracted and standardized using high-performance liquid chromatography (HPLC), and their phenolic constituents were determined. Meanwhile, the Olea europaea L. oil was tested for its purity. The extracts were evaluated for their effect in the treatment of polycystic ovary syndrome (PCOS). Tribulus arabicus showed the highest flavonoid content. HPLC analyses of the phenolic, flavonoid, and vitamin constituents of the different extracts were carried out. All the extracts and the O. europaea oil showed high antioxidant activities. The biochemical measurements showed a significant difference between rats treated with natural remedies and letrozole. Some extracts significantly reduced the elevated levels of triglycerides, cholesterol, low-density lipoprotein, and glucose compared to metformin. Progesterone and follicle-stimulating hormone levels increased, but luteinizing hormone and testosterone levels decreased in all the treated groups. Marked reduction in the elevated tumor necrosis factor-alpha and malondialdehyde levels with an increased superoxide dismutase level was observed. The histopathological data also supported the potential effect of the remedies. The results showed that P. emblica and P. americana were viable alternatives to metformin for the treatment of PCOS
摘要译文
这项研究旨在调查和研究五种天然产物作为治疗卵巢囊肿并将其生物学活性与活性成分相关的替代品的有效性以及功效。使用高性能液相色谱（HPLC）提取并标准化了植物膜的水果，三角洲仙网菌种子，甘蓝橄榄石花朵和persea omericana果实。同时，Olea Europaea L.石油的纯度进行了测试。评估了提取物在治疗多囊卵巢综合征（PCOS）方面的作用。阿拉伯tribul虫显示出最高的类黄酮含量。进行了不同提取物的酚类，类黄酮和维生素成分的HPLC分析。所有提取物和O. europaea油都表现出较高的抗氧化活性。生化测量结果显示，用天然疗法和letrozole处理的大鼠之间存在显着差异。与二甲双胍相比，一些提取物显着降低了甘油三酸酯，胆固醇，低密度脂蛋白和葡萄糖的升高水平。孕酮和卵泡刺激的激素水平增加，但在所有治疗组中，黄体生成激素和睾丸激素水平都降低。观察到较高的肿瘤坏死因子-Alpha和丙二醛水平降低，超氧化物歧化酶水平升高。组织病理学数据还支持疗法的潜在影响。结果表明，emblica和P. americana是二甲双胍治疗PCOS的可行替代品
Naglaa Gamil Shehab; Hanan S. Anbar; Nadia Mahmoud Alrouby; Aya Abouelalamin; Lama Lutfi; Israa Tyseer Allo; Salma Mohamed Elayoty. New alternative herbal remedies for treatment of letrozole-induced polycystic ovary syndrome in rats[J]. Journal of Applied Pharmaceutical Science, 2023,13(1): 163-179