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The effect of testosterone in mice divergently selected on fat content or body weight 收藏

The effect of testosterone in mice divergently selected on fat content or body weight
原文求助 发布源
作者
IAN M. HASTINGS
作者单位
[1]Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
发布日期
01 October 1997
页码
135-141
DOI
10.1017/S0016672397002905
来源信息
Genetics Research ISSN：0016-6723, 1997年, 70卷, 2期, 135-141页
摘要
Lines of mice have been divergently selected on one of two traits: (i) estimated fat content at 14 weeks of age, which has resulted in a 5-fold divergence, and (ii) body weight at 10 weeks of age, which has resulted in a 3-fold divergence. Individuals from each line were castrated or sham operated at 10 days of age and subsequently given either exogenous testosterone or the appropriate control from 14 days of age. Castration increased fat content and decreased lean weight in all lines, an effect which was not reversed by administration of testosterone. Body weight was reduced by around 10% as a result of castration and this effect was at least partially reversed by exogenous testosterone. Analysis of body weight, fat content and lean mass at 10 weeks of age failed to detect any interaction between these treatments and genetic background. It is therefore concluded that testosterone metabolism has not contributed disproportionately to the response to artificial selection in spite of its known effects on growth and body composition.
摘要译文
Lines of mice have been divergently selected on one of two traits: (i) estimated fat content at 14 weeks of age, which has resulted in a 5-fold divergence, and (ii) body weight at 10 weeks of age, which has resulted in a 3-fold divergence. Individuals from each line were castrated or sham operated at 10 days of age and subsequently given either exogenous testosterone or the appropriate control from 14 days of age. Castration increased fat content and decreased lean weight in all lines, an effect which was not reversed by administration of testosterone. Body weight was reduced by around 10% as a result of castration and this effect was at least partially reversed by exogenous testosterone. Analysis of body weight, fat content and lean mass at 10 weeks of age failed to detect any interaction between these treatments and genetic background. It is therefore concluded that testosterone metabolism has not contributed disproportionately to the response to artificial selection in spite of its known effects on growth and body composition.
IAN M. HASTINGS. The effect of testosterone in mice divergently selected on fat content or body weight[J]. Genetics Research, 1997,70(2): 135-141