期刊文献

Activating or Inhibiting Nrf2? 收藏

激活或抑制Nrf2？

原文求助发布源

作者

Xin-YiChu[1];Ye-MaoLiu[1];Hong-YuZhang[1];

作者单位

[1]Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, ChinaCorrespondence:

关键词

Nrf2; activator; inhibitor; oxidative stress;

关键词译文

Nrf2的;激活;抑制剂;氧化应激;

发布日期

1 November 2017

页码

953-955

DOI

10.1016/j.tips.2017.08.002

来源信息

Trends in Pharmacological Sciences ISSN：0165-6147, 2017年, 38卷, 11期, 953-955页

摘要

Activating nuclear factor erythroid 2 (NF-E2)-related factor (Nrf2) is a widely recognized strategy for combating oxidative-stress-induced diseases. However, Nrf2 activation does not always bring advantageous effects. Therefore, before performing Nrf2-targeted therapy, we must pinpoint whether Nrf2 should be activated or inhibited.

摘要译文

激活核因子红细胞2（NF-E2）相关因子（Nrf2）是一种广泛认可的对抗氧化应激诱导的疾病的策略。然而，Nrf2激活并不总是带来有利的效果。因此，在进行Nrf2靶向治疗之前，我们必须确定是否应激活或抑制Nrf2。

Xin-YiChu[1];Ye-MaoLiu[1];Hong-YuZhang[1];. Activating or Inhibiting Nrf2?[J]. Trends in Pharmacological Sciences, 2017,38(11): 953-955