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Identification of cancer-specific cell surface targets for CAR-T cell therapy 收藏

Identification of cancer-specific cell surface targets for CAR-T cell therapy
原文求助 发布源
作者
Hosen; Naoki
关键词
CAR-T cell;Lineage-specific antigens;Post-translational modification;
关键词译文
CAR-T cell;Lineage-specific antigens;Post-translational modification;
发布日期
29 March 2024
DOI
10.1186/s41232-024-00329-2
来源信息
Inflammation and Regeneration ISSN：1880-9693, 2024年, 44卷, 1期
摘要
One should identify appropriate cell surface targets to develop new CAR-T cells. Currently, lineage-specific antigens such as CD19 or B cell maturation antigen (BCMA) are being used as targets for CAR-T cells. However, in most cancers, lineage-specific antigens cannot be used as targets because targeting normal counterparts expressing them causes fatal toxicity. Cancer-specific transcripts have been extensively searched for using transcriptome analysis, but only a few candidates were reported. We have been working on identifying tumor-specific antigen structures, for example constitutively activated conformer of integrin b7 in multiple myeloma. Recently, several researchers have been working on a logic gate system that can react only when two antigens are expressed on the cell surface.
摘要译文
One should identify appropriate cell surface targets to develop new CAR-T cells. Currently, lineage-specific antigens such as CD19 or B cell maturation antigen (BCMA) are being used as targets for CAR-T cells. However, in most cancers, lineage-specific antigens cannot be used as targets because targeting normal counterparts expressing them causes fatal toxicity. Cancer-specific transcripts have been extensively searched for using transcriptome analysis, but only a few candidates were reported. We have been working on identifying tumor-specific antigen structures, for example constitutively activated conformer of integrin b7 in multiple myeloma. Recently, several researchers have been working on a logic gate system that can react only when two antigens are expressed on the cell surface.
Hosen; Naoki. Identification of cancer-specific cell surface targets for CAR-T cell therapy[J]. Inflammation and Regeneration, 2024,44(1)