摘要
The effects of ovarian steroids on baseline blood pressure and on changes of mean arterial pressure in response to centrally administered angiotensin II, prostaglandin E1, and prostaglandin E2 were examined. Ovariectomized rats treated with estradiol or progesterone showed no change of resting blood pressures relative to oil-treated, ovariectomized controls. Intracerebroventricular injections of prostaglandin E1, prostaglandin E2 or angiotensin II produced significant elevations of arterial pressure of oil-treated rats. Either estradiol or progesterone treatment significantly attenuated pressor responses to prostaglandin E1 but not to prostaglandin E2 or angiotensin II injections. The duration of the blood pressure increase of estradiol-treated rats in response to angiotensin II was reduced when the animals did not have access to drinking water during the pressure monitoring session but not when water was available. These results’suggest that the effects of ovarian steroids in modulating pressor responses are dependent on the particular factors which initiate the pressure increases. Possible mechanisms underlying this ovarian-steroid action are discussed.
摘要译文
检查了卵巢类固醇对基线血压和对中央给药的血管紧张素II，前列腺素E 1和前列腺素E2响应的平均动脉压变化的影响。与经油处理，去卵巢的对照组相比，用雌二醇或孕酮治疗的去卵巢大鼠未表现出静息血压的变化。脑室内注射前列腺素E 1，前列腺素E 2或血管紧张素II使经油治疗的大鼠的动脉压显着升高。雌二醇或孕酮治疗均显着降低了对前列腺素E 1的升压反应，但对前列腺素E 2或血管紧张素II注射却没有。当动物在压力监测过程中没有喝水但没有水供应时，响应血管紧张素II的雌二醇处理的大鼠血压升高的持续时间减少了。这些结果表明，卵巢类固醇在调节升压反应中的作用取决于引起压力升高的特定因素。讨论了这种卵巢-类固醇作用的潜在机制。
Skoog K.M. Kenney N.J.. Pressor Responses to Central Angiotensin II, Prostaglandin E1 and Prostaglandin E2[J]. Neuroendocrinology, 1983,36(2): 144-151