摘要
A single intramuscular injection of MnCl2 in mice caused an increase in macrophage functional activity. Spleen cell antibody-dependent cell-mediated cytotoxicity against both chicken erythrocytes and P815 tumor cell targets was enhanced 24 h following a single injection of MnCl2. Enhanced antibody-dependent cell-mediated cytotoxicity activity following MnCl2 treatment was not associated with a change in spleen cellularities compared with saline-injected mice. Resident peritoneal macrophages from mice injected intramuscularly with MnCl2 displayed enhanced phagocytic activity for chicken erythrocytes in the presence or absence of opsonizing antibody. Enhanced cytolytic activity against P815 mastocytoma target cells and enhanced cytostatic activity against MBL-2 lymphoma target cells was also observed for nonelicited resident peritoneal macrophages from mice injected intramuscularly with MnCl2. There were no differences in the cellularity or relative number of adherent cells obtained from the peritoneal cavity of saline of MNCl2-injected mice. These enhanced macrophage functions were associated with the induction of increased interferon levels in mice injected with MnCl2.
摘要译文
在小鼠中单次肌内注射MnCl 2引起巨噬细胞功能活性的增加。在单次注射MnCl 2后24小时，增强了针对鸡红细胞和P815肿瘤细胞靶标的脾细胞抗体依赖性细胞介导的细胞毒性。与注射盐水的小鼠相比，MnCl 2处理后增强的抗体依赖性细胞介导的细胞毒性活性与脾细胞的变化无关。来自用MnCl 2肌内注射的小鼠的常驻腹膜巨噬细胞在调理抗体存在或不存在下显示出对鸡红细胞的增强的吞噬活性。对于来自用MnCl 2肌内注射的小鼠的非小鼠的腹膜巨噬细胞，也观察到针对P815肥大细胞瘤靶细胞的增强的细胞溶解活性和对MBL-2淋巴瘤靶细胞的增强的细胞抑制活性。从注射MNCl 2的小鼠的盐水的腹膜腔获得的贴壁细胞的细胞性或相对数量没有差异。这些增强的巨噬细胞功能与注射MnCl 2的小鼠中诱导增加的干扰素水平相关。
Ralph J. Smialowicz Robert W. Luebke Ronald R. Rogers Marie M. Riddle Denise G. Rowe. Manganese chloride enhances natural cell-mediated immune effector cell function: Effects on macrophages[J]. Immunopharmacology, 1985,9(1): 1-11