摘要
Larvicides are used to control sea lamprey (Petromyzon marinus) in the Great Lakes. These larvicides are useful because they are more toxic to sea lamprey than fish species found in the same habitat. The lampricides come from two classes of chemical compounds: (1) halonitrophenols, and (2) halonitrosalicylanilides. Selectivity of the larvicides appears to be based on the differences in the ability of sea lamprey larvae and fishes to detoxify and/or excrete the chemicals. Glucuronide conjugation is an important mechanism for detoxification of these larvicides by fish, and selectivity of larvicides may be due to differences in glucuronyl transferase activity between lamprey and fishes. If more detailed information were available on uptake, metabolism, excretion, and the biochemistry and physiology of lamprey as compared to fishes, it might be possible to design chemicals that would be more selective than those now in use.Key words: sea lamprey, larvicides, selective toxicity, uptake, metabolism, excretion, halonitrophenols
摘要译文
杀幼虫用于控制五大湖中的海鳗（Petromyzon marinus）。这些杀幼虫剂是有用的，因为它们对海鲷的毒性比在同一栖息地中发现的鱼类毒性更大。萤火虫来自两类化合物：（1）卤代硝基苯酚，和（2）卤代硝基水杨酰苯胺。杀幼虫剂的选择性似乎是基于海鳗幼虫和鱼类解毒和/或排泄化学物质的能力的差异。葡萄糖醛酸结合是鱼类对这些杀幼虫剂进行解毒的重要机制，并且杀幼虫剂的选择性可能是由于七鳃鳗和鱼类之间的葡糖醛酸基转移酶活性的差异。如果有更多关于七鳃鳗的摄取，代谢，排泄以及生物化学和生理学的详细信息，那么有可能设计出比现在使用的更具选择性的化学物质。关键词：海鳗，杀幼虫，选择性毒性，摄取，代谢，排泄，halonitrophenols
John H. Howell; ; John J. Lech; and ; John L. Allen. Development of Sea Lamprey (Petromyzon marinus) Larvicides[J]. Canadian Journal of Fisheries and Aquatic Sciences, 1980,37(11): 2103-2107