摘要
Despite some progress in recent years, the fight against parasitic diseases still remains a great challenge. Parasitic diseases affect primarily (but not exclusively) the poorest people living in underdeveloped regions of the world. The distribution of parasitoses are linked to tropical and subtropical climate conditions, to population growth and to impoverishment. If not treated, parasitic diseases may lead to serious health problems, and even death. Particularly vulnerable groups include infants and young children, pregnant women and immunocompromised individuals. Polyether ionophore antibiotics (ionophores), traditionally used in veterinary medicine as anti-coccidial feed additives and non-hormonal growth promoters, are of considerable interest, as they have been found to be highly effective agents against various parasites, both in vitro and in vivo. This review summarizes the anti-parasitic effects of the most important polyether ionophores against parasites that are responsible for a number of animal and human parasitic diseases. Recent findings and advances that support the potential of polyether ionophore antibiotics as novel anti-parasitic drug candidates are also presented and discussed.
摘要译文
尽管近年来取得了一些进展，但抗击寄生虫病仍然是一项巨大的挑战。寄生虫病主要影响（但不仅限于）生活在世界欠发达地区的最贫困人口。寄生虫的分布与热带和亚热带气候条件，人口增长和贫困有关。如果不治疗，寄生虫病可能导致严重的健康问题，甚至死亡。特别脆弱的群体包括婴儿和幼儿，孕妇和免疫功能低下的人。聚醚离子载体抗生素（离子载体），传统上用于兽医学中作为抗球虫饲料添加剂和非激素生长促进剂，具有相当大的意义，因为它们已被发现是体外和体内各种寄生虫的高效药物。 。该综述总结了最重要的聚醚离子载体对寄生虫的抗寄生虫作用，寄生虫是造成许多动物和人类寄生虫病的原因。还提出并讨论了支持聚醚离子载体抗生素作为新型抗寄生虫候选药物的潜力的最新发现和进展。
MichałAntoszczak[a];DietmarSteverding[b];AdamHuczyński[a];. Anti-parasitic activity of polyether ionophores[J]. European Journal of Medicinal Chemistry, 2019,166: 32-47