期刊文献

Phyto-SERM Constitutes from Flemingia macrophylla 收藏

Phyto-SERM由Flemingia macrophylla构成
原文求助 发布源
作者
Wan-Chun Lai[ 1]; Ya-Ting Tsui[ 1]; Abdel Nasser B. Singab[ 2]; Mohamed El-Shazly[ 1;2]; Ying-Chi Du[ 1]; Tsong-Long Hwang[ 3]; Chin-Chung Wu[ 1]; Ming-Hong Yen[ 1]; Ching-Kuo Lee[ 4]; Ming-Feng Hou[ 5]; Yang-Chang Wu[ 6;7;8;][*] ;Fang-Rong Chang[ 1;5;][*]
作者单位
[1] Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan [2] Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street, Abassia, Cairo 11566, Egypt [3] Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan [4] Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110, Taiwan [5] Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan [6] School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan [7] Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan [8] Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan [*] Authors to whom correspondence should be addressed.
关键词
Flemingia macrophylla; menopausal; phytoestrogen; fleminigin; flemichin E; pER8:GUS
关键词译文
Flemingia macrophylla;更年期;植物雌激素; fleminigin; flemichin E; pER8：GUS
发布日期
26 July 2013
页码
15578-15594
DOI
10.3390/ijms140815578
来源信息
International Journal of Molecular Sciences ISSN：1422-0067, 2013年, 14卷, 8期, 15578-15594页
摘要
The methanolic extract of Flemingia macrophylla roots exhibited significant estrogenic activity in the transgenic plant assay system which was comparable to the activity of soybean extract. Utilizing estrogenic activity-guided fractionation, one new compound, fleminigin, together with 23 known compounds were isolated from F. macrophylla roots’ methanolic extract. The structure of the new compound was identified based on intensive spectroscopic analysis and the full spectral data for one of the isolated compounds, flemichin E, was introduced for the first time in the current investigation. The estrogenic and anti-estrogenic activities of the isolated compounds were evaluated revealing that the isolated isoflavonoids may act as partial estrogen agonists, as well as antagonists. Additionally, the anti-inflammatory and the cytotoxic activities of the isolated compounds were studied. These results suggested the potential applications of F. macrophylla extract and its isolated compounds as selective estrogen receptor modulators (SERMs).
摘要译文
Flemingia macrophylla根的甲醇提取物在转基因植物测定系统中表现出显着的雌激素活性，其与大豆提取物的活性相当。利用雌激素活性引导的分级分离，从大叶黄杨（F. macrophylla）根的甲醇提取物中分离出一种新化合物fleminigin和23种已知化合物。基于强光谱分析鉴定了新化合物的结构，并且在当前研究中首次引入了一种分离的化合物flemichin E的全光谱数据。评估分离的化合物的雌激素和抗雌激素活性，揭示分离的异黄酮可以作为部分雌激素激动剂以及拮抗剂。另外，研究了分离的化合物的抗炎和细胞毒活性。这些结果表明大叶黄杨提取物及其分离的化合物作为选择性雌激素受体调节剂（SERMs）的潜在应用。
Wan-Chun Lai[ 1]; Ya-Ting Tsui[ 1]; Abdel Nasser B. Singab[ 2]; Mohamed El-Shazly[ 1;2]; Ying-Chi Du[ 1]; Tsong-Long Hwang[ 3]; Chin-Chung Wu[ 1]; Ming-Hong Yen[ 1]; Ching-Kuo Lee[ 4]; Ming-Feng Hou[ 5]; Yang-Chang Wu[ 6;7;8;][*] ;Fang-Rong Chang[ 1;5;][*] . Phyto-SERM Constitutes from Flemingia macrophylla[J]. International Journal of Molecular Sciences, 2013,14(8): 15578-15594