摘要
The aim of this randomized cross-over study was to determine whether direct intraperitoneal insemination (DIPI) is superior to intrauterine insemination (IUI) in hyperstimulated cycles. The treatment cycles were stimulated with either clomiphene citrate and human menopausal gonadotrophins, or buserelin and human menopausal gonadotrophins. 207 subfertile couples with a cervical factor, a male factor, a combined cervical and male factor, or an unexplained subfertility were randomly assigned to the first treatment cycle. IUI and DIPI were performed in alternate cycles to a maximum of 6 cycles per couple. Every treatment cycle was followed by a nontreatment cycle. The pregnancy rate per completed cycle was 24% for IUI and 16% for DIPI (p = 0.018), whereas the cumulative pregnancy rates for IUI and DIPI were 53 and 40%, respectively (p = 0.002). There were no significant differences between pregnancy rates for IUI and DIPI in the different categories of subfertility. We conclude that DIPI does not offer better pregnancy chances than IUI in superovulated cycles.
摘要译文
这项随机交叉研究的目的是确定在过度刺激的周期中直接腹膜内人工授精（DIPI）是否优于子宫内人工授精（IUI）。用柠檬酸克罗米芬和人类更年期促性腺激素或布塞林和人类更年期促性腺激素刺激治疗周期。将207例具有子宫颈因子，雄性因子，子宫颈和雄性因子合并或不明原因的不育性的不育夫妇随机分配到第一个治疗周期。 IUI和DIPI交替进行，每对最多6个循环。每个治疗周期之后是非治疗周期。 IUI和DIPI的每个完整周期的妊娠率分别为24％和16％（p = 0.018），而IUI和DIPI的累积妊娠率分别为53％和40％（p = 0.002）。在不同类型的亚生育力中，IUI和DIPI的妊娠率之间没有显着差异。我们得出结论，在超排卵周期中，DIPI不能提供比IUI更好的怀孕机会。
Tiemessen C.H.J.[a] Bots R.S.G.M.[a] Peeters M.F.[a] Evers J.L.H.[b]. Direct Intraperitoneal Insemination Compared to Intrauterine Insemination in Superovulated Cycles: A Randomized Cross-Over Study[J]. Gynecologic and Obstetric Investigation, 1997,44(3): 149-152