摘要
Marine bioresources are a valuable source of bioactive compounds with industrial and nutraceutical potential. Numerous clinical trials evaluating novel chemotherapeutic agents derived from marine sources have revealed novel mechanisms of action. Recently, marine-derived bioactive peptides have attracted attention owing to their numerous beneficial effects. Moreover, several studies have reported that marine peptides exhibit various anti-infective activities, such as antimicrobial, antifungal, antimalarial, antiprotozoal, anti-tuberculosis, and antiviral activities. In the last several decades, studies of marine plants, animals, and microbes have revealed tremendous number of structurally diverse and bioactive secondary metabolites. However, the treatments available for many infectious diseases caused by bacteria, fungi, and viruses are limited. Thus, the identification of novel antimicrobial peptides should be continued, and all possible strategies should be explored. In this review, we will present the structures and anti-infective activity of peptides isolated from marine sources (sponges, algae, bacteria, fungi and fish) from 2006 to the present.
摘要译文
海洋生物资源是具有工业和营养保健潜力的生物活性化合物的宝贵来源。评估源自海洋来源的新型化学治疗剂的许多临床试验揭示了新的作用机制。最近，海洋衍生的生物活性肽由于其众多有益效果而引起了关注。此外，一些研究报道海洋肽表现出各种抗感染活性，例如抗微生物，抗真菌，抗疟，抗原虫，抗结核和抗病毒活性。在过去的几十年中，对海洋植物，动物和微生物的研究揭示了大量结构多样且具有生物活性的次生代谢产物。然而，可用于由细菌，真菌和病毒引起的许多传染病的治疗是有限的。因此，应继续鉴定新型抗菌肽，并应探索所有可能的策略。在这篇综述中，我们将介绍从2006年到现在从海洋来源（海绵，藻类，细菌，真菌和鱼类）中分离的肽的结构和抗感染活性。
Hee Kyoung Kang[ 1]; Chang Ho Seo[ 2];Yoonkyung Park[ 1;3;][*] . Marine Peptides and Their Anti-Infective Activities[J]. Marine Drugs, 2015,13(1): 618-654