摘要
From the initial discovery in 1999 that NADPH oxidases comprise a family of enzymes to our current focus on drug development to treat multiple pathologies related to this enzyme family, progress has been swift and impressive. We have expanded our understanding of the extent of the family, the basic enzymatic biochemistry, the multiple cellular functions controlled by NADPH oxidases, and their varied roles in physiology and diseases. We have developed numerous cell culture tools, animal models, a
摘要译文
从1999年的初始发现中，NADPH氧化酶包含对我们目前对药物开发的重点是对药物开发来治疗与该酶家族有关的多种病理的一系列酶，进展已经迅速和令人印象深刻。我们已经扩大了我们对家族程度，基本酶生物化学，由NADPH氧化酶控制的多细胞功能的理解，以及它们在生理学和疾病中的各种角色。我们开发了许多细胞培养工具，动物模型，a
Alejandra San Martin;Kathy K. Griendling.. NADPH Oxidases: Progress and Opportunities[J]. Antioxidants & Redox Signaling, 2014,20(17): 2692-2694